Role of Lactobacillus plantarum 299v versus Placebo in symptomatic improvement of irritable bowel syndrome patients.
- 2022-02-03
- JPMA. The Journal of the Pakistan Medical Association 72(3)
- Ahmad Nawaz Babar
- Muhammad Kamran Hassan
- Fazl Ullah
- Anwar Ullah
- PubMed: 35320214
- DOI: 10.47391/jpma.0758
Objectives
To find the efficacy of lactobacillus plantarum 299v compared to placebo in symptomatic improvement of irritable bowel syndrome patients.Methods
The randomised control trial was conducted at the Lady Reading Hospital, Peshawar, Pakistan, from July 20, 2014, to January 20, 2015, and comprised irritable bowel syndrome patients who were randomised into intervention group A treated with lactobacillus plantarum 299v and control group B treated with placebo. Symptoms, like abdominal pain, bloating and complete rectal emptying, were noted and compared between the groups. Data was analysed using SPSS 19.Results
Of the 190 patients assessed, 120(63%) were included; 60(50%) in each of the two groups. After loss to follow-up, the study was completed by 55(91.7%) in group A and 53(88.3%) in group B. The mean age in group A was 37.53±9.02 and it was 34.40±11.23 in group B (p=0.652). The male-to-female ratio and irritable bowel syndrome type in both the groups was not significantly different (p>0.055). There was no significant difference in terms of relieving abdominal pain, bloating and rectal emptying between the groups (p>0.05).Conclusions
No significant efficacy was established in favour of treating in irritable bowel syndrome with lactobacillus plantarum 299v.Trials registration
IRCT20200504047303N1.Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus plantarum 299v | Reduced Abdominal Pain | Neutral | Small |
| Lactobacillus plantarum 299v | Reduced Bloating | Neutral | Small |
| Lactobacillus plantarum 299v | Reduced Irritable Bowel Syndrome Symptoms | Neutral | Small |