Best Supplements for Reduced Fatigue
Ranked by research evidence. Compare 42 supplements across 58 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence4 studies
Across all 4 studies, lavender aromatherapy shows moderate evidence for reducing fatigue, with all 4 reporting beneficial effects and statistically significant results. The predominant effect size was moderate across 3 studies and large in 1 study. The most-studied dose was nightly inhalation of lavender essential oil, and the median study duration was 18 days, suggesting benefits can appear within weeks in clinical populations.
Dose: nightly inhalation of lavender essential oil (e.g., 15-minute sessions or 2 minutes before bed, for 5-28 days) - Moderate evidence4 studies
Across 4 studies (1 randomized controlled trial, 3 reviews), all reported beneficial effects of Lactobacillus brevis SBC8803 on reducing fatigue, with effect sizes ranging from small to moderate. The single RCT (n=53 healthy adults) showed a statistically significant moderate improvement in exercise performance and fatigue markers after six weeks. Most evidence comes from secondary reviews, and no consistent dose or form data are available.
- Very low evidence3 studies
Across 3 studies, all reported beneficial effects on fatigue reduction, with a predominant moderate effect size (2 moderate, 1 small). The evidence is limited to narrative reviews and one animal study; no human clinical trials with this specific strain were identified. No dose, form, or duration data are available.
- ModerateLavenderAcross all 4 studies, lavender aromatherapy shows moderate evidence for reducing fatigue, with all 4 reporting beneficial effects and statistically significant results. The predominant effect size was moderate across 3 studies and large in 1 study. The most-studied dose was nightly inhalation of lavender essential oil, and the median study duration was 18 days, suggesting benefits can appear within weeks in clinical populations. · Dose: nightly inhalation of lavender essential oil (e.g., 15-minute sessions or 2 minutes before bed, for 5-28 days)4 beneficial4 studies
- ModerateLactobacillus brevis SBC8803Across 4 studies (1 randomized controlled trial, 3 reviews), all reported beneficial effects of Lactobacillus brevis SBC8803 on reducing fatigue, with effect sizes ranging from small to moderate. The single RCT (n=53 healthy adults) showed a statistically significant moderate improvement in exercise performance and fatigue markers after six weeks. Most evidence comes from secondary reviews, and no consistent dose or form data are available.4 beneficial4 studies
- Very lowLactobacillus salivarius UCC118Across 3 studies, all reported beneficial effects on fatigue reduction, with a predominant moderate effect size (2 moderate, 1 small). The evidence is limited to narrative reviews and one animal study; no human clinical trials with this specific strain were identified. No dose, form, or duration data are available.3 beneficial3 studies