Lactobacillus salivarius UCC118 and Reduced Fatigue

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all 3 reported beneficial effects on reducing fatigue, with two showing moderate-sized effects and one showing a small effect. One statistically significant finding comes from an animal study, while the remaining evidence consists of narrative reviews summarizing mechanistic and preclinical data. No consistent dose or specific human population has been established.

Caveats: All 3 studies are either narrative reviews or an animal study; no human RCTs directly testing Lactobacillus salivarius UCC118 for fatigue are included. The significant finding is from a mouse model, limiting direct applicability to humans.

Generated May 10, 2026

3 of 3 papers

Gut Microbiota and Exercise-Induced Fatigue: A Narrative Review of Mechanisms, Nutritional Interventions, and Future Directions.
- 2026-02-02
- Review
- Nutrients 18(3)
- - Zhengxin Zhao
  - Shengwei Zhao
  - Wenli Li
  - Zheng Lai
  - Yang Zhou
  - Feng Guan
  - Xu Liang
  - Jiawei Zhang
  - Linding Wang
- PubMed: 41683324
- DOI: 10.3390/nu18030502
3 Insights on
- Reduced Fatigue
- Moderate evidence
- Rigorous Journal
Current evidence supports a mechanistic role of the gut microbiota in EIF and highlights microbiota-targeted nutrition as a promising adjunct for recovery optimization
Effect
Beneficial
Effect size
Moderate
Gut Microbiota and Exercise: Probiotics to Modify the Composition and Roles of the Gut Microbiota in the Context of 3P Medicine.
- 2025-05-03
- Review
- Microbial ecology 88(1)
- - Yongfu Liu
  - Yuting Hu
  - Baolei Ma
  - Zijun Wang
  - Bowen Wei
- PubMed: 40319213
- DOI: 10.1007/s00248-025-02529-w
2 Insights on
- Reduced Fatigue
- Low evidence
This review explores the mechanisms through which probiotics may enhance exercise performance, mitigate exercise-induced fatigue, and improve physiological adaptation via modulation of inflammation, oxidative stress, and metabolic signaling pathways.
Effect
Beneficial
Effect size
Small
Lactobacillus salivarius Subspecies salicinius SA-03 is a New Probiotic Capable of Enhancing Exercise Performance and Decreasing Fatigue
- 2020-04-09
- Microorganisms 8(4)
- - Mon-Chien Lee
  - Y. Hsu
  - H. Ho
  - Shih‐Hung Hsieh
  - Y. Kuo
  - Hsin‐Ching Sung
  - Chi-Chang Huang
- PubMed: 32283729
- DOI: 10.3390/microorganisms8040545
13 Insights on
- Reduced Fatigue
- Low evidence
- Rigorous Journal
decreased lactate, blood urea nitrogen (BUN), ammonia, and creatine kinase (CK) levels after exercise
Effect
Beneficial
Effect size
Moderate
Significant
Yes

Lactobacillus salivarius UCC118 and Reduced Fatigue

Gut Microbiota and Exercise-Induced Fatigue: A Narrative Review of Mechanisms, Nutritional Interventions, and Future Directions.

Gut Microbiota and Exercise: Probiotics to Modify the Composition and Roles of the Gut Microbiota in the Context of 3P Medicine.

Lactobacillus salivarius Subspecies salicinius SA-03 is a New Probiotic Capable of Enhancing Exercise Performance and Decreasing Fatigue