Lactobacillus brevis SBC8803 and Reduced Fatigue

Research synthesisLow evidenceMixed effect size4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 studies, all reported beneficial effects of Lactobacillus brevis SBC8803 on reducing fatigue, with effect sizes ranging from small to moderate. The only randomized controlled trial (RCT) found a statistically significant moderate effect on exercise performance and fatigue in healthy adults (n=53). Three review articles also cited benefits, but the overall evidence base is small and the most-studied dose, form, and duration are not consistently reported.

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Only one study was a primary RCT; the other three were reviews, which may rely on overlapping primary sources. Doses, forms, and study durations were not reported in the available data, limiting the ability to generalize findings.

Generated Jun 11, 2026

4 of 4 papers

Different Impacts of Heat-Killed and Viable Lactiplantibacillus plantarum TWK10 on Exercise Performance, Fatigue, Body Composition, and Gut Microbiota in Humans.
- 2022-11-03
- RCT
- Microorganisms 10(11)
- - Chia-Chia Lee
  - Yi-Chu Liao
  - Mon-Chien Lee
  - Yi-Chen Cheng
  - Shiou-Yun Chiou
  - Jin-Seng Lin
  - Chi-Chang Huang
  - Koichi Watanabe
- PubMed: 36363775
- DOI: 10.3390/microorganisms10112181
7 Insights on
- Reduced Fatigue
- High evidence
After six-week administration, both the TWK10 and TWK10-hk groups had significantly improved exercise performance and fatigue-associated features and reduced exercise-induced inflammation, compared with controls.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
The human microbiome in space: parallels between Earth-based dysbiosis, implications for long-duration spaceflight, and possible mitigation strategies.
- 2024-09-12
- Review
- Clinical microbiology reviews 37(3)
- - Sofia Etlin
  - Julianna Rose
  - Luca Bielski
  - Claire Walter
  - Ashley S Kleinman
  - Christopher E Mason
- PubMed: 39136453
- DOI: 10.1128/cmr.00163-22
3 Insights on
- Reduced Fatigue
- Low evidence
consuming Lactobacillus brevis SBC8803 was associated with reduced feelings of fatigue
Effect
Beneficial
Effect size
Small
Probiotics and Postbiotics as the Functional Food Components Affecting the Immune Response.
- 2022-12-31
- Review
- Microorganisms 11(1)
- - Aleksandra Szydłowska
  - Barbara Sionek
- PubMed: 36677396
- DOI: 10.3390/microorganisms11010104
3 Insights on
- Reduced Fatigue
- Low evidence
consumption of Lactobacillus brevis SBC8803 was shown to decrease stress and stress-related fatigue
Effect
Beneficial
Effect size
Moderate
Gut Microbiome and Space Travelers' Health: State of the Art and Possible Pro/Prebiotic Strategies for Long-Term Space Missions.
- 2020-09-08
- Review
- Frontiers in physiology 11
- - Silvia Turroni
  - Marciane Magnani
  - Pukar Kc
  - Philippe Lesnik
  - Hubert Vidal
  - Martina Heer
- PubMed: 33013480
- DOI: 10.3389/fphys.2020.553929
5 Insights on
- Reduced Fatigue
- Low evidence
Lactobacillus brevis SBC8803 has been reported to improve subjective symptoms associated with cold and fatigue in healthy adults.
Effect
Beneficial
Effect size
Small

Lactobacillus brevis SBC8803 and Reduced Fatigue

Different Impacts of Heat-Killed and Viable Lactiplantibacillus plantarum TWK10 on Exercise Performance, Fatigue, Body Composition, and Gut Microbiota in Humans.

The human microbiome in space: parallels between Earth-based dysbiosis, implications for long-duration spaceflight, and possible mitigation strategies.

Probiotics and Postbiotics as the Functional Food Components Affecting the Immune Response.

Gut Microbiome and Space Travelers' Health: State of the Art and Possible Pro/Prebiotic Strategies for Long-Term Space Missions.