Lactobacillus brevis SBC8803 and Reduced Fatigue

Research synthesisModerate evidenceMixed effect size4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 studies (1 randomized controlled trial, 3 reviews), all reported beneficial effects of Lactobacillus brevis SBC8803 on reducing fatigue, with effect sizes ranging from small to moderate. The single RCT (n=53 healthy adults) showed a statistically significant moderate improvement in exercise performance and fatigue markers after six weeks. Most evidence comes from secondary reviews, and no consistent dose or form data are available.

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Additionally, three of the four studies are reviews summarizing other research; only one is a primary trial. No dose, form, or population details were consistently reported across studies.

Generated Jul 12, 2026

4 of 4 papers

Different Impacts of Heat-Killed and Viable Lactiplantibacillus plantarum TWK10 on Exercise Performance, Fatigue, Body Composition, and Gut Microbiota in Humans.
- 2022-11-03
- RCT
- Microorganisms 10(11)
- - Chia-Chia Lee
  - Yi-Chu Liao
  - Mon-Chien Lee
  - Yi-Chen Cheng
  - Shiou-Yun Chiou
  - Jin-Seng Lin
  - Chi-Chang Huang
  - Koichi Watanabe
- PubMed: 36363775
- DOI: 10.3390/microorganisms10112181
7 Insights on
- Reduced Fatigue
- High evidence
After six-week administration, both the TWK10 and TWK10-hk groups had significantly improved exercise performance and fatigue-associated features and reduced exercise-induced inflammation, compared with controls.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
The human microbiome in space: parallels between Earth-based dysbiosis, implications for long-duration spaceflight, and possible mitigation strategies.
- 2024-09-12
- Review
- Clinical microbiology reviews 37(3)
- - Sofia Etlin
  - Julianna Rose
  - Luca Bielski
  - Claire Walter
  - Ashley S Kleinman
  - Christopher E Mason
- PubMed: 39136453
- DOI: 10.1128/cmr.00163-22
3 Insights on
- Reduced Fatigue
- Low evidence
consuming Lactobacillus brevis SBC8803 was associated with reduced feelings of fatigue
Effect
Beneficial
Effect size
Small
Probiotics and Postbiotics as the Functional Food Components Affecting the Immune Response.
- 2022-12-31
- Review
- Microorganisms 11(1)
- - Aleksandra Szydłowska
  - Barbara Sionek
- PubMed: 36677396
- DOI: 10.3390/microorganisms11010104
3 Insights on
- Reduced Fatigue
- Low evidence
consumption of Lactobacillus brevis SBC8803 was shown to decrease stress and stress-related fatigue
Effect
Beneficial
Effect size
Moderate
Gut Microbiome and Space Travelers' Health: State of the Art and Possible Pro/Prebiotic Strategies for Long-Term Space Missions.
- 2020-09-08
- Review
- Frontiers in physiology 11
- - Silvia Turroni
  - Marciane Magnani
  - Pukar Kc
  - Philippe Lesnik
  - Hubert Vidal
  - Martina Heer
- PubMed: 33013480
- DOI: 10.3389/fphys.2020.553929
5 Insights on
- Reduced Fatigue
- Low evidence
Lactobacillus brevis SBC8803 has been reported to improve subjective symptoms associated with cold and fatigue in healthy adults.
Effect
Beneficial
Effect size
Small

Lactobacillus brevis SBC8803 and Reduced Fatigue

Different Impacts of Heat-Killed and Viable Lactiplantibacillus plantarum TWK10 on Exercise Performance, Fatigue, Body Composition, and Gut Microbiota in Humans.

The human microbiome in space: parallels between Earth-based dysbiosis, implications for long-duration spaceflight, and possible mitigation strategies.

Probiotics and Postbiotics as the Functional Food Components Affecting the Immune Response.

Gut Microbiome and Space Travelers' Health: State of the Art and Possible Pro/Prebiotic Strategies for Long-Term Space Missions.