Best Supplements for Improved Health-related Quality of Life
Ranked by research evidence. Compare 17 supplements across 21 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence3 studies
Across 3 studies, 2 reported beneficial effects on health-related quality of life, with one showing a moderate effect size and the other a small effect; the third study found a neutral effect. The beneficial effects were observed in children with ADHD, while a small neutral trial involved adults with mild-to-moderate ulcerative colitis. The median study duration was 28 days, but effects were noted at longer follow-up (3 months) in one trial; dose information was largely not reported, limiting generalizability.
- Low evidence3 studies
Across 3 studies, 1 reported a beneficial small effect on health-related quality of life, while 2 higher-quality studies (a meta-analysis and an RCT) found neutral effects. The predominant effect size is small. Most evidence comes from clinical populations (e.g., postmenopausal breast cancer, ulcerative colitis, Hashimoto's thyroiditis), and the only study reporting duration (28 days) showed no benefit over placebo.
Product matchViva Naturals — Vitamin D3 with Organic Liquid Coconut Oil125 mcg · $15.16 · ★5.0 (208)
- LowLactobacillus rhamnosus GGAcross 3 studies, 2 reported beneficial effects on health-related quality of life, with one showing a moderate effect size and the other a small effect; the third study found a neutral effect. The beneficial effects were observed in children with ADHD, while a small neutral trial involved adults with mild-to-moderate ulcerative colitis. The median study duration was 28 days, but effects were noted at longer follow-up (3 months) in one trial; dose information was largely not reported, limiting generalizability.2 beneficial1 neutral3 studies
- LowVitamin DAcross 3 studies, 1 reported a beneficial small effect on health-related quality of life, while 2 higher-quality studies (a meta-analysis and an RCT) found neutral effects. The predominant effect size is small. Most evidence comes from clinical populations (e.g., postmenopausal breast cancer, ulcerative colitis, Hashimoto's thyroiditis), and the only study reporting duration (28 days) showed no benefit over placebo.1 beneficial2 neutral3 studies