Best Supplements for Improved Health-related Quality of Life
Ranked by research evidence. Compare 17 supplements across 21 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence3 studies
Across 3 studies, 2 reported beneficial effects of Lactobacillus rhamnosus GG on health-related quality of life, with effect sizes ranging from small to moderate; 1 study found a neutral effect. The strongest evidence (an RCT in children with ADHD) showed a moderate beneficial effect (d = 0.53), while a pilot RCT in ulcerative colitis patients found no added benefit over placebo. The median study duration was 28 days (1 of 3 studies reported duration), limiting conclusions about long-term effects.
- Low evidence3 studies
Across 3 studies, 1 reported a beneficial small effect on health-related quality of life, while 2 higher-quality studies (a meta-analysis and an RCT) found neutral effects. The predominant effect size is small. Most evidence comes from clinical populations (e.g., postmenopausal breast cancer, ulcerative colitis, Hashimoto's thyroiditis), and the only study reporting duration (28 days) showed no benefit over placebo.
Product matchViva Naturals — Vitamin D3 with Organic Liquid Coconut Oil125 mcg · $15.16 · ★5.0 (208)
- LowLactobacillus rhamnosus GGAcross 3 studies, 2 reported beneficial effects of Lactobacillus rhamnosus GG on health-related quality of life, with effect sizes ranging from small to moderate; 1 study found a neutral effect. The strongest evidence (an RCT in children with ADHD) showed a moderate beneficial effect (d = 0.53), while a pilot RCT in ulcerative colitis patients found no added benefit over placebo. The median study duration was 28 days (1 of 3 studies reported duration), limiting conclusions about long-term effects.2 beneficial1 neutral3 studies
- LowVitamin DAcross 3 studies, 1 reported a beneficial small effect on health-related quality of life, while 2 higher-quality studies (a meta-analysis and an RCT) found neutral effects. The predominant effect size is small. Most evidence comes from clinical populations (e.g., postmenopausal breast cancer, ulcerative colitis, Hashimoto's thyroiditis), and the only study reporting duration (28 days) showed no benefit over placebo.1 beneficial2 neutral3 studies