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Evidence-Based Supplement Research
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Lactobacillus rhamnosus GG and Improved Health-related Quality of Life

Research synthesisLow evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial effects on health-related quality of life, with one showing a moderate effect size and the other a small effect; the third study found a neutral effect. The beneficial effects were observed in children with ADHD, while a small neutral trial involved adults with mild-to-moderate ulcerative colitis. The median study duration was 28 days, but effects were noted at longer follow-up (3 months) in one trial; dose information was largely not reported, limiting generalizability.

  • Studied populations: children with attention deficit hyperactivity disorder (ADHD)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The two beneficial studies both involved children with ADHD and were smaller or based on a systematic review; the one neutral RCT in adults with UC suggests the effect may not generalize to other clinical populations. Dosing was not specified in most studies, and the median study duration of 28 days may be insufficient to observe effects in some contexts.

Generated Jun 25, 2026
Time to effect
Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 3 studies
3 of 3 papers
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