Best Supplements for Reduced HOMA-IR
Ranked by research evidence. Compare 18 supplements across 22 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence4 studies
Across 4 meta-analyses, 3 reported beneficial effects of vitamin D supplementation on reducing HOMA-IR, with effect sizes ranging from small to moderate. The one neutral study also noted a statistically significant reduction for vitamin D2 compared to D3, but the overall effect was classified as neutral. Evidence is drawn exclusively from clinical populations including obese children, patients with diabetes/prediabetes, and those with MAFLD. No consistent dose range or study duration was reported across studies.
Product matchViva Naturals — Vitamin D3 with Organic Liquid Coconut Oil125 mcg · $15.16 · ★5.0 (208)
18 supplements
- ModerateVitamin DAcross 4 meta-analyses, 3 reported beneficial effects of vitamin D supplementation on reducing HOMA-IR, with effect sizes ranging from small to moderate. The one neutral study also noted a statistically significant reduction for vitamin D2 compared to D3, but the overall effect was classified as neutral. Evidence is drawn exclusively from clinical populations including obese children, patients with diabetes/prediabetes, and those with MAFLD. No consistent dose range or study duration was reported across studies.2 beneficial2 neutral4 studies