Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Vitamin D and Reduced HOMA-IR

Research synthesisModerate evidenceSmall effect5 studies · 3 beneficial · 2 neutral · 0 harmful

Across 5 meta-analyses, 3 reported beneficial effects of vitamin D supplementation on reducing HOMA-IR, with effect sizes ranging from small to moderate. One study in children found a neutral effect despite a statistically significant reduction with vitamin D2 versus D3, while another in general populations reported a neutral non-significant result. The most studied population was clinical patients with diabetes or metabolic conditions, but dose ranges were inconsistently reported.

  • Studied populations: patients with diabetes and prediabetes, obese/overweight children and adolescents, patients with metabolic-associated fatty liver disease

Caveats: Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Form differences were noted: one study found vitamin D2 more effective than D3 for HOMA-IR reduction, but forms were not consistently reported across studies.

Generated Jul 11, 2026
5 of 5 papers
Back to top