Best Supplements for Increased HDL Cholesterol Levels
Ranked by research evidence. Compare 64 supplements across 77 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence4 studies
Across 4 studies, turmeric/curcumin supplementation showed a mixed effect on HDL cholesterol, with 2 studies reporting beneficial effects (small to moderate) and 2 finding neutral results. The two beneficial studies were meta-analyses showing statistically significant increases in HDL, while the two neutral RCTs found non-significant trends or no change. The median study duration was 87 days (approx. 12 weeks) among the 2 RCTs that reported duration. The most studied populations were clinical groups (Hashimoto's thyroiditis, hemodialysis, type 2 diabetes, metabolic syndrome).
- Low evidence3 studies
Across 3 studies, 2 reported beneficial effects of rice bran or rice bran oil on HDL cholesterol levels, with effect sizes ranging from small to large, while 1 meta-analysis found no significant effect. The median study duration was 42 days, suggesting effects may be observed within 4–8 weeks. Doses varied, with one study using 30 g/day of rice bran oil and another using fortified bread providing an unspecified dose of defatted rice bran.
- LowTurmericAcross 4 studies, turmeric/curcumin supplementation showed a mixed effect on HDL cholesterol, with 2 studies reporting beneficial effects (small to moderate) and 2 finding neutral results. The two beneficial studies were meta-analyses showing statistically significant increases in HDL, while the two neutral RCTs found non-significant trends or no change. The median study duration was 87 days (approx. 12 weeks) among the 2 RCTs that reported duration. The most studied populations were clinical groups (Hashimoto's thyroiditis, hemodialysis, type 2 diabetes, metabolic syndrome).2 beneficial2 neutral4 studies
- Lowrice branAcross 3 studies, 2 reported beneficial effects of rice bran or rice bran oil on HDL cholesterol levels, with effect sizes ranging from small to large, while 1 meta-analysis found no significant effect. The median study duration was 42 days, suggesting effects may be observed within 4–8 weeks. Doses varied, with one study using 30 g/day of rice bran oil and another using fortified bread providing an unspecified dose of defatted rice bran.2 beneficial1 neutral3 studies