Best Supplements for Increased HDL Cholesterol Levels
Ranked by research evidence. Compare 49 supplements across 56 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence4 studies
Across 4 studies, 2 reported beneficial effects of turmeric on increasing HDL cholesterol, while 2 found neutral effects. Among the beneficial studies, effect sizes were small to moderate (one small, one moderate), and both were statistically significant. The median study duration was 87 days (about 12 weeks), and the most-studied population was clinical (e.g., patients with Hashimoto's thyroiditis, hemodialysis patients, type 2 diabetes or metabolic syndrome). No clear dose range emerged due to variability in reporting.
- Low evidence3 studies
Across 3 studies, 2 reported beneficial effects of rice bran on HDL cholesterol, with effect sizes ranging from small to large. One meta-analysis found no significant effect. Median study duration was 42 days. The evidence is mixed but promising in specific populations.
Dose: Defatted rice bran (DRB)-fortified bread (3–4 slices daily) and 30 g/d of rice bran oil
- LowTurmericAcross 4 studies, 2 reported beneficial effects of turmeric on increasing HDL cholesterol, while 2 found neutral effects. Among the beneficial studies, effect sizes were small to moderate (one small, one moderate), and both were statistically significant. The median study duration was 87 days (about 12 weeks), and the most-studied population was clinical (e.g., patients with Hashimoto's thyroiditis, hemodialysis patients, type 2 diabetes or metabolic syndrome). No clear dose range emerged due to variability in reporting.2 beneficial2 neutral4 studies
- Lowrice branAcross 3 studies, 2 reported beneficial effects of rice bran on HDL cholesterol, with effect sizes ranging from small to large. One meta-analysis found no significant effect. Median study duration was 42 days. The evidence is mixed but promising in specific populations. · Dose: Defatted rice bran (DRB)-fortified bread (3–4 slices daily) and 30 g/d of rice bran oil2 beneficial1 neutral3 studies