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Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: a randomized, double-blind, placebo-controlled trial

  • 2018
  • Bioscience of Microbiota, Food and Health 37(3)
    • J. Minami
    • N. Iwabuchi
    • Miyuki Tanaka
    • K. Yamauchi
    • J. Xiao
    • F. Abe
    • N. Sakane

Abstract

Accumulating evidence suggests a relationship between the gut microbiota and the development of obesity, indicating the potential of probiotics as a therapeutic approach. Bifidobacterium breve B-3 has been shown to exert anti-obesity effects in high-fat diet-induced obese mice. In the present study, the anti-obesity effects of the consumption of B. breve B-3 by healthy pre-obese (25 ≤ BMI < 30) adults were investigated in a randomized, double-blind, placebo-controlled trial (trial registration: UMIN-CTR No. 000023919; preregistered on September 2, 2016). Eighty participants were randomized to receive placebo or B. breve B-3 capsules (2 × 1010 CFU/day) daily for 12 weeks. The visceral fat area significantly increased at weeks 4 and 8 in the placebo group only; no significant change was observed in the B-3 group. Body fat mass and percent body fat were significantly lower in the B-3 group than in the placebo group at weeks 8 and 12 (p<0.05, ANCOVA adjusted with baseline values). Although no significant differences were observed in blood parameters between the groups, the intake of B. breve B-3 slightly decreased triglyceride levels and improved HDL cholesterol from the baseline. No serious adverse effects were noted in either group. These results suggest that the probiotic strain B. breve B-3 has potential as a functional food ingredient to reduce body fat in healthy pre-obese individuals.

Keywords: Bifidobacterium breve; body fat reduction; pre-obese; randomized controlled trial.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium breveImproved HDL Cholesterol LevelsBeneficial
Small
Bifidobacterium breveReduced Body Fat MassBeneficial
Moderate
Bifidobacterium breveReduced Visceral Fat AreaBeneficial
Moderate
Bifidobacterium breve Bb-03Improved HDL Cholesterol LevelsBeneficial
Small
Bifidobacterium breve Bb-03Reduced Body FatBeneficial
Moderate
Bifidobacterium breve Bb-03Reduced Body Fat MassBeneficial
Moderate
Bifidobacterium breve Bb-03Reduced Triglyceride LevelsBeneficial
Small
Bifidobacterium breve Bb-03Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium breve Bb-18Improved HDL Cholesterol LevelsBeneficial
Small
Bifidobacterium breve Bb-18Reduced Body Fat MassBeneficial
Moderate
Bifidobacterium breve Bb-18Reduced Visceral FatBeneficial
Moderate
Bifidobacterium breve Bbr8Improved HDL Cholesterol LevelsBeneficial
Small
Bifidobacterium breve Bbr8Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium breve BR-03Improved Triglyceride LevelsBeneficial
Small
Bifidobacterium breve BR-03No Serious Adverse EffectsNeutral
Moderate
Bifidobacterium breve BR-03Reduced Body Fat MassBeneficial
Moderate
Bifidobacterium breve BR-03Reduced Visceral FatBeneficial
Moderate
Bifidobacterium breve BR03Improved HDL Cholesterol LevelsBeneficial
Small
Bifidobacterium breve BR03Reduced Body Fat MassBeneficial
Moderate
Bifidobacterium breve BR03Stabilized Visceral Fat AreaBeneficial
Moderate
Bifidobacterium breve HA-129Increased HDL Cholesterol LevelsBeneficial
Small
Bifidobacterium breve HA-129Reduced Body FatBeneficial
Moderate
Bifidobacterium breve HA-129Reduced Visceral FatBeneficial
Moderate
Bifidobacterium breve IDCC 4401Improved HDL Cholesterol LevelsBeneficial
Small
Bifidobacterium breve IDCC 4401Reduced Body FatBeneficial
Moderate
Bifidobacterium breve IDCC 4401Reduced Body Fat MassBeneficial
Moderate
Bifidobacterium breve IDCC 4401Reduced Triglyceride LevelsBeneficial
Small
Bifidobacterium breve IDCC 4401Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium breve M-16VImproved Blood Lipid ProfileNeutral
Small
Bifidobacterium breve M-16VReduced Body Fat MassBeneficial
Moderate
Bifidobacterium breve M-16VStabilized Visceral Fat AreaBeneficial
Moderate
Bifidobacterium breve MAK40B22BImproved HDL Cholesterol LevelsBeneficial
Small
Bifidobacterium breve MAK40B22BReduced Body Fat MassBeneficial
Moderate
Bifidobacterium breve MAK40B22BReduced Visceral Fat AreaBeneficial
Moderate
Bifidobacterium breve R0070Increased HDL Cholesterol LevelsBeneficial
Small
Bifidobacterium breve R0070Reduced Triglyceride LevelsBeneficial
Small
Bifidobacterium breve R0070Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium breve Rosell-70Improved HDL Cholesterol LevelsBeneficial
Small
Bifidobacterium breve Rosell-70Reduced Abdominal Visceral Fat AreaBeneficial
Moderate
Bifidobacterium breve Rosell-70Reduced Body Fat MassBeneficial
Moderate
Bifidobacterium breve SD5206Reduced Visceral Fat AreaBeneficial
Moderate
Bifidobacterium breve UABbr-11Improved HDL Cholesterol LevelsBeneficial
Small
Bifidobacterium breve UABbr-11Reduced Abdominal Visceral Fat AreaBeneficial
Moderate
Bifidobacterium breve UABbr-11Reduced Body Fat MassBeneficial
Moderate
Bifidobacterium breve VPro 52Improved HDL Cholesterol LevelsBeneficial
Small
Bifidobacterium breve VPro 52Reduced Body Fat MassBeneficial
Moderate
Bifidobacterium breve VPro 52Reduced Triglyceride LevelsBeneficial
Small
Bifidobacterium breve VPro 52Reduced Visceral FatBeneficial
Moderate
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