Best Supplements for Improved Clinical Attachment
Ranked by research evidence. Compare 19 supplements across 29 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence5 studies
Across 5 studies, 3 reported beneficial moderate-sized effects on clinical attachment level, while 1 found a neutral effect and 1 reported a harmful small effect. The overall evidence indicates a moderate beneficial effect in periodontitis patients, with statistically significant improvements in 4 studies (including the harmful one). Effects were typically observed over 8–12 weeks to 6 months (median study duration 118 days).
- Low evidence4 studies
Across 4 studies, 3 reported beneficial effects of propolis on clinical attachment level, while 1 showed a neutral effect. The predominant effect size is moderate. The evidence is mixed between a small neutral effect in a large meta-analysis (315 T2D patients) and moderate beneficial effects in other meta-analyses, with limited convergence on specific doses, durations, or populations.
- ModerateLactobacillus reuteriAcross 5 studies, 3 reported beneficial moderate-sized effects on clinical attachment level, while 1 found a neutral effect and 1 reported a harmful small effect. The overall evidence indicates a moderate beneficial effect in periodontitis patients, with statistically significant improvements in 4 studies (including the harmful one). Effects were typically observed over 8–12 weeks to 6 months (median study duration 118 days).3 beneficial1 neutral1 harmful5 studies
- LowPropolisAcross 4 studies, 3 reported beneficial effects of propolis on clinical attachment level, while 1 showed a neutral effect. The predominant effect size is moderate. The evidence is mixed between a small neutral effect in a large meta-analysis (315 T2D patients) and moderate beneficial effects in other meta-analyses, with limited convergence on specific doses, durations, or populations.3 beneficial1 neutral4 studies