Best Supplements for Improved Clinical Attachment
Ranked by research evidence. Compare 18 supplements across 26 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence5 studies
Across 5 studies on Lactobacillus reuteri for improved clinical attachment, 3 reported beneficial effects (moderate in 2, small in 1), 1 was neutral, and 1 was harmful. Effect sizes were moderate in the beneficial studies, but the evidence is mixed. Most studies enrolled clinical populations with periodontitis, and effects were typically observed at 56–180 days.
Dose: 1×10⁹ CFU/day - Very low evidence3 studies
Across 3 studies on propolis for improved clinical attachment, 2 reported beneficial effects (1 moderate, 1 small) and 1 found neutral effects. The one statistically significant finding was from a review on nano-bio fusion gel containing propolis, which showed a small beneficial effect. The evidence base is very small, and no consistent dose or form has been reported.
- LowLactobacillus reuteriAcross 5 studies on Lactobacillus reuteri for improved clinical attachment, 3 reported beneficial effects (moderate in 2, small in 1), 1 was neutral, and 1 was harmful. Effect sizes were moderate in the beneficial studies, but the evidence is mixed. Most studies enrolled clinical populations with periodontitis, and effects were typically observed at 56–180 days. · Dose: 1×10⁹ CFU/day3 beneficial1 neutral1 harmful5 studies
- Very lowPropolisAcross 3 studies on propolis for improved clinical attachment, 2 reported beneficial effects (1 moderate, 1 small) and 1 found neutral effects. The one statistically significant finding was from a review on nano-bio fusion gel containing propolis, which showed a small beneficial effect. The evidence base is very small, and no consistent dose or form has been reported.2 beneficial1 neutral3 studies