Best Supplements for Improved Clinical Attachment
Ranked by research evidence. Compare 18 supplements across 24 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence4 studies
Across 4 studies, 2 reported beneficial moderate-sized effects, 1 found neutral small effects, and 1 reported harmful small effects on clinical attachment levels with Lactobacillus reuteri supplementation. The evidence is mixed, with the largest beneficial effect observed in a 2025 RCT of 120 periodontitis patients using 1×10⁹ CFU/day for 56 days, while a systematic review of 369 patients found no significant benefit. Studies lasted a median of 118 days, and all but one study was in clinical populations with periodontitis or gingivitis.
Dose: 1×10⁹ CFU/day - Very low evidence3 studies
Across 3 studies on propolis for improved clinical attachment, 2 reported beneficial effects (1 moderate, 1 small) and 1 found neutral effects. The one statistically significant finding was from a review on nano-bio fusion gel containing propolis, which showed a small beneficial effect. The evidence base is very small, and no consistent dose or form has been reported.
- LowLactobacillus reuteriAcross 4 studies, 2 reported beneficial moderate-sized effects, 1 found neutral small effects, and 1 reported harmful small effects on clinical attachment levels with Lactobacillus reuteri supplementation. The evidence is mixed, with the largest beneficial effect observed in a 2025 RCT of 120 periodontitis patients using 1×10⁹ CFU/day for 56 days, while a systematic review of 369 patients found no significant benefit. Studies lasted a median of 118 days, and all but one study was in clinical populations with periodontitis or gingivitis. · Dose: 1×10⁹ CFU/day2 beneficial1 neutral1 harmful4 studies
- Very lowPropolisAcross 3 studies on propolis for improved clinical attachment, 2 reported beneficial effects (1 moderate, 1 small) and 1 found neutral effects. The one statistically significant finding was from a review on nano-bio fusion gel containing propolis, which showed a small beneficial effect. The evidence base is very small, and no consistent dose or form has been reported.2 beneficial1 neutral3 studies