Propolis and Improved Clinical Attachment

Research synthesisLow evidenceModerate effect4 studies · 3 beneficial · 1 neutral · 0 harmful

Across 4 studies, 3 reported beneficial effects of propolis on clinical attachment level, while 1 showed a neutral effect. The predominant effect size is moderate. The evidence is mixed between a small neutral effect in a large meta-analysis (315 T2D patients) and moderate beneficial effects in other meta-analyses, with limited convergence on specific doses, durations, or populations.

Studied populations: patients with periodontitis, including type 2 diabetes patients

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Many included studies are reviews or meta-analyses with limited sample size details; the highest-quality study (a 2025 meta-analysis, evidence score 6) found a neutral small effect, contrasting with other moderate beneficial findings, suggesting potential inconsistency in results.

Generated Jul 18, 2026

4 of 4 papersPopulation:

The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis.
- 2025-12-01
- Meta-Analysis · n = 315
- Clinical and experimental dental research 11(6)
- - Sara A Abdulla
  - Bushra A Abdalla
  - Aisha Ali Muhammed
  - Hayam A Elawamy
  - Salima M Hawda
  - Najah Mohamed
  - Enass H Abduallah
  - Mustafa Y G Younis
  - Hajir Omar Alsanfaz
  - Hiba Abdelmunim Suliman
- PubMed: 41158097
- DOI: 10.1002/cre2.70215
4 Insights on
- Improved Clinical Attachment
- High evidence
- Clinical
vitamin C and O3FAs had minimal impact
Effect
Neutral
Effect size
Small
Significant
No
Propolis effects in periodontal disease seem to affect coronavirus disease: a meta-analysis.
- 2023
- Meta-Analysis
- Brazilian oral research 37
- - Silvia Helena de Carvalho Sales-Peres
  - Lucas José de Azevedo-Silva
  - Ana Virginia Santana Sampaio Castilho
  - Marcelo Salmazo Castro
  - André de Carvalho Sales-Peres
  - Maria Aparecida de Andrade Moreira Machado
- PubMed: 37018812
- DOI: 10.1590/1807-3107bor-2023.vol37.0031
5 Insights on
- Improved Clinical Attachment
- High evidence
The meta-analysis showed favorable results with the use of propolis on...clinical attachment level (95%CI: 1.48; p < 0.001)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Comparison Between Natural Products and Chlorhexidine in Non-Surgical Periodontal Therapy: A Systematic Review of Randomized Clinical Trials.
- 2026-02-13
- Review
- Dentistry journal 14(2)
- - Andrea Scribante
  - Matteo Pellegrini
  - Maurizio Pascadopoli
  - Valentino Natoli
  - Valentina Poma
  - Andrea Butera
- PubMed: 41744948
- DOI: 10.3390/dj14020110
4 Insights on
- Improved Clinical Attachment
- Low evidence
- Clinical
Natural products such as Curcuma longa, Morus alba, Spirulina platensis, Propolis, Triphala, and Lycium barbarum demonstrated improvements in clinical attachment level (CAL) and probing pocket depth (PPD) comparable to those obtained with CHX
Effect
Beneficial
Effect size
Moderate
Clinical Applications and Therapeutic Potential of Nano-Bio Fusion Gel in Oral Soft Tissue Therapy: A Critical Narrative Review.
- 2026-05-14
- Review
- Gels (Basel, Switzerland) 12(5)
- - Gábor Kammerhofer
  - Ákos Tamás Nagy
  - Árpád Joób-Fancsaly
  - György Szmirnov
  - Ilona Szmirnova
  - Dániel Végh
  - Márton Kivovics
  - György Szabó
  - Zsolt Németh
- PubMed: 42196113
- DOI: 10.3390/gels12050429
11 Insights on
- Improved Clinical Attachment
- Low evidence
- Clinical
NBF gel may provide clinical benefits as an adjunct to non-surgical periodontal therapy, with reported improvements in clinical attachment level
Effect
Beneficial
Effect size
Small
Significant
Yes

Propolis and Improved Clinical Attachment

The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis.

Propolis effects in periodontal disease seem to affect coronavirus disease: a meta-analysis.

Comparison Between Natural Products and Chlorhexidine in Non-Surgical Periodontal Therapy: A Systematic Review of Randomized Clinical Trials.

Clinical Applications and Therapeutic Potential of Nano-Bio Fusion Gel in Oral Soft Tissue Therapy: A Critical Narrative Review.