Propolis and Improved Clinical Attachment

Research synthesisLow evidenceMixed effect size3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies on propolis for improved clinical attachment, 2 reported beneficial effects (1 small, 1 moderate), and 1 was neutral (small effect). The predominant effect size is small to moderate. Studies reviewed populations with periodontitis, including a meta-analysis which found minimal impact, while a systematic review noted improvements comparable to chlorhexidine.

Studied populations: patients with periodontitis, T2D patients with periodontitis

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests.

Generated Jul 12, 2026

3 of 3 papers

The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis.
- 2025-12-01
- Meta-Analysis · n = 315
- Clinical and experimental dental research 11(6)
- - Sara A Abdulla
  - Bushra A Abdalla
  - Aisha Ali Muhammed
  - Hayam A Elawamy
  - Salima M Hawda
  - Najah Mohamed
  - Enass H Abduallah
  - Mustafa Y G Younis
  - Hajir Omar Alsanfaz
  - Hiba Abdelmunim Suliman
- PubMed: 41158097
- DOI: 10.1002/cre2.70215
4 Insights on
- Improved Clinical Attachment
- High evidence
- Clinical
vitamin C and O3FAs had minimal impact
Effect
Neutral
Effect size
Small
Significant
No
Comparison Between Natural Products and Chlorhexidine in Non-Surgical Periodontal Therapy: A Systematic Review of Randomized Clinical Trials.
- 2026-02-13
- Review
- Dentistry journal 14(2)
- - Andrea Scribante
  - Matteo Pellegrini
  - Maurizio Pascadopoli
  - Valentino Natoli
  - Valentina Poma
  - Andrea Butera
- PubMed: 41744948
- DOI: 10.3390/dj14020110
4 Insights on
- Improved Clinical Attachment
- Low evidence
- Clinical
Natural products such as Curcuma longa, Morus alba, Spirulina platensis, Propolis, Triphala, and Lycium barbarum demonstrated improvements in clinical attachment level (CAL) and probing pocket depth (PPD) comparable to those obtained with CHX
Effect
Beneficial
Effect size
Moderate
Clinical Applications and Therapeutic Potential of Nano-Bio Fusion Gel in Oral Soft Tissue Therapy: A Critical Narrative Review.
- 2026-05-14
- Review
- Gels (Basel, Switzerland) 12(5)
- - Gábor Kammerhofer
  - Ákos Tamás Nagy
  - Árpád Joób-Fancsaly
  - György Szmirnov
  - Ilona Szmirnova
  - Dániel Végh
  - Márton Kivovics
  - György Szabó
  - Zsolt Németh
- PubMed: 42196113
- DOI: 10.3390/gels12050429
11 Insights on
- Improved Clinical Attachment
- Low evidence
- Clinical
NBF gel may provide clinical benefits as an adjunct to non-surgical periodontal therapy, with reported improvements in clinical attachment level
Effect
Beneficial
Effect size
Small
Significant
Yes

Propolis and Improved Clinical Attachment

The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis.

Comparison Between Natural Products and Chlorhexidine in Non-Surgical Periodontal Therapy: A Systematic Review of Randomized Clinical Trials.

Clinical Applications and Therapeutic Potential of Nano-Bio Fusion Gel in Oral Soft Tissue Therapy: A Critical Narrative Review.