Best Supplements for Reduced Pain
Ranked by research evidence. Compare 41 supplements across 51 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence4 studies
Across 4 studies, 3 reported beneficial effects on pain reduction, with effect sizes ranging from small to large (mixed). One study found no significant effect. The median study duration was 90 days (reported in one study). Populations included recurrent aphthous stomatitis, rheumatoid arthritis, chronic lower back pain, and chronic pain.
- Low evidence3 studies
Across 3 studies, 2 reported beneficial moderate-sized effects of L-Arginine on reducing pain in clinical populations (sickle cell disease vaso-occlusive episodes and radiation-induced oral mucositis), while 1 meta-analysis found no significant benefit. The two beneficial RCTs used short-term dosing (100 mg/kg/dose three times/day in children or 5 g/day in adults) and showed effects within days to 7 weeks. The evidence base is small and includes a neutral meta-analysis, limiting the generalizability of the positive findings.
Product matchKirkman Labs — Amino Support with Free Form Essential Amino Acids & AKG· $54.00 · ★5.0 (23)
- ModerateTurmericAcross 4 studies, 3 reported beneficial effects on pain reduction, with effect sizes ranging from small to large (mixed). One study found no significant effect. The median study duration was 90 days (reported in one study). Populations included recurrent aphthous stomatitis, rheumatoid arthritis, chronic lower back pain, and chronic pain.3 beneficial1 neutral4 studies
- LowL-ArginineAcross 3 studies, 2 reported beneficial moderate-sized effects of L-Arginine on reducing pain in clinical populations (sickle cell disease vaso-occlusive episodes and radiation-induced oral mucositis), while 1 meta-analysis found no significant benefit. The two beneficial RCTs used short-term dosing (100 mg/kg/dose three times/day in children or 5 g/day in adults) and showed effects within days to 7 weeks. The evidence base is small and includes a neutral meta-analysis, limiting the generalizability of the positive findings.2 beneficial1 neutral3 studies