Dietary interventions and nutritional strategies for menopausal health: a mini review.

2025-12-15
Frontiers in nutrition 12
- Yi-Chen Liu
- Zhi-Qing Guo

PubMed: 41473185
DOI: 10.3389/fnut.2025.1702105

Study Design

Type: Review
Population: peri- and postmenopausal women
Methods: structured searches of PubMed/MEDLINE, Scopus, Web of Science, and Cochrane Library; narrative synthesis incorporating critical appraisal of study quality, heterogeneity, and bias

Menopause constitutes a pivotal physiological transition characterized by irreversible cessation of ovarian function and profound estrogen depletion, precipitating vasomotor symptoms, accelerated bone resorption, heightened cardiovascular risk, and adverse metabolic reprogramming. This mini-review systematically synthesizes evidence from 42 high-quality studies (18 systematic reviews/meta-analyses and 24 randomized controlled trials) published between January 2020 and October 2025. Studies were sourced via structured searches of PubMed/MEDLINE, Scopus, Web of Science, and Cochrane Library, focusing on dietary patterns and targeted nutrient interventions in peri- and postmenopausal women (inclusion: outcomes on vasomotor symptoms, bone health, cardiovascular risk, or metabolic parameters; exclusion: hormone replacement therapy or non-human research). Narrative synthesis incorporated critical appraisal of study quality, heterogeneity, and bias. Adherence to the Mediterranean diet consistently demonstrates clinically meaningful reductions in blood pressure and triglyceride concentrations, thereby attenuating cardiovascular burden. Calcium and vitamin D co-supplementation robustly preserves bone mineral density and mitigates fracture risk. Plant-based dietary patterns rich in whole grains, fruits, and vegetables are associated with attenuated symptom severity and enhanced healthy aging trajectories. Despite these advances, postmenopausal women remain disproportionately vulnerable to micronutrient deficiencies, underscoring the imperative for balanced, nutrient-dense intake. These non-pharmacological strategies confer substantial improvements in quality of life, yet persistent gaps in long-term outcomes and representation of diverse populations necessitate further investigation.

Research Insights

Calcium→Preserved Bone Mineral Density
Calcium and vitamin D co-supplementation robustly preserves bone mineral density and mitigates fracture risk.
Effect
Beneficial
Effect size
Moderate
Calcium→Reduced Fracture Risk
Calcium and vitamin D co-supplementation robustly preserves bone mineral density and mitigates fracture risk.
Effect
Beneficial
Effect size
Moderate
Vitamin D→Preserved Bone Mineral Density
Calcium and vitamin D co-supplementation robustly preserves bone mineral density and mitigates fracture risk.
Effect
Beneficial
Effect size
Moderate
Vitamin D→Reduced Fracture Risk
Calcium and vitamin D co-supplementation robustly preserves bone mineral density and mitigates fracture risk.
Effect
Beneficial
Effect size
Moderate

Adverse Events Reported

Vitamin D→Overall tolerability
Calcium and vitamin D co-supplementation robustly preserves bone mineral density and mitigates fracture risk.
Finding
Reported
Calcium→Overall tolerability
Calcium and vitamin D co-supplementation robustly preserves bone mineral density and mitigates fracture risk.
Finding
Reported
Vitamin D→micronutrient deficiencies
Despite these advances, postmenopausal women remain disproportionately vulnerable to micronutrient deficiencies, underscoring the imperative for balanced, nutrient-dense intake.
Finding
Reported
Calcium→micronutrient deficiencies
Despite these advances, postmenopausal women remain disproportionately vulnerable to micronutrient deficiencies, underscoring the imperative for balanced, nutrient-dense intake.
Finding
Reported