Effect of ginseng and ginsenosides on attention deficit hyperactivity disorder: A systematic review.
- 2024-09
- Journal of ginseng research 48(5)
- Yunna Kim
- Ik-Hyun Cho
- Seung-Hun Cho
- PubMed: 39263306
- DOI: 10.1016/j.jgr.2024.05.006
Study Design
- Type
- Review
- Methods
- Systematic review of PubMed, Embase, Cochrane Library, and Web of Science up to June 2023; included both human and animal studies
Attention deficit hyperactivity disorder (ADHD) is a rapidly increasing neurodevelopmental disorder but currently available treatments are associated with abuse risk, side effects, and incomplete symptom relief. There is growing interest in exploring complementary options, and ginseng has gained attention for its therapeutic potential. This systematic review aimed to assess current evidence on the efficacy of ginseng and its active components, ginsenosides, for ADHD. Eligible studies were identified through searches of PubMed, Embase, Cochrane Library, and Web of Science, up to June 2023. The inclusion criteria included both human and animal studies that investigated the effects of ginseng or ginsenosides on ADHD. The risk of bias was assessed according to study type. Six human studies and three animal studies met the inclusion criteria. The results suggest that ginseng and ginsenosides may have beneficial effects on ADHD symptoms, particularly inattention, through dopaminergic/norepinephrinergicmodulation and BDNF/TrkB signaling. Ginseng and ginsenosides have promising potential for ADHD treatment. Due to limitations in evidence quality, such as the risk of bias and variability in study designs, larger controlled studies are essential. Integrating ginseng into ADHD management may have valuable implications for individuals seeking well-tolerated alternatives or adjunctive therapies.
Research Insights
The results suggest that ginseng and ginsenosides may have beneficial effects on ADHD symptoms, particularly inattention, through dopaminergic/norepinephrinergic modulation and BDNF/TrkB signaling.
- Effect
- Beneficial
- Effect size
- Moderate
The results suggest that ginseng and ginsenosides may have beneficial effects on ADHD symptoms, particularly inattention, through dopaminergic/norepinephrinergic modulation and BDNF/TrkB signaling.
- Effect
- Beneficial
- Effect size
- Moderate
Adverse Events Reported
Ginseng and ginsenosides have promising potential for ADHD treatment.
- Finding
- Reported
Ginseng and ginsenosides have promising potential for ADHD treatment.
- Finding
- Reported