Effectiveness of gastrodin for migraine: A meta-analysis.

2022-08-25
Frontiers in neurology 13
- Xiu Zhou
- Jingyi Shao
- Xiuzhen Xie
- Yingqi Xu
- Tianyu Shao
- Zhuqing Jin

PubMed: 36090869
DOI: 10.3389/fneur.2022.939401

Study Design

Type: Systematic Review
Sample size: n = 332
Population: 1,332 subjects with migraine
Methods: Meta-analysis of 16 RCTs, searched ten databases up to September 2021, data analyzed by RevMan 5.3 and evaluated by GRADEpro
Funding: Unclear

Background

Gastrodia elata Blume (GEB), a traditional Chinese medicine, has been widely used to treat dizziness, numbness of limbs, and infantile convulsion, among other issues. Gastrodin is the main component of GEB. This meta-analysis aimed to evaluate the efficacy and safety of gastrodin in the treatment of migraine.

Methods

Ten electronic databases, namely the Cochrane Library, Embase, EBSCO, PubMed, Web of Science, CENTRAL, CNKI (China National Knowledge Infrastructure), CBM (Chinese Biomedicine Database), WanFang, and VIP (Chinese Scientific Journals Database), were searched for randomized controlled trials (RCTs) of gastrodin for migraine published before September 2021. The data were analyzed by RevMan 5.3 software and evaluated by GRADEpro.

Results

A total of 1,332 subjects were included in 16 RCTs. The meta-analysis showed that gastrodin was significantly effective in treating migraine (RR = 1.21, 95%CI = [1.17, 1.27]), reducing the pain degree (MD = -1.65, 95% CI = [-2.28, -1.02]), reducing the frequency of migraine attack (SMD = -2.77, 95% CI = [-3.92, -1.62]), shortening the duration of migraine attack (SMD = -1.64, 95% CI = [-2.35, -0.93]), and slowing average arterial cerebral blood flow velocity (SMD = -3.19, 95% CI = [-5.21, -1.17]), as well as being safe.

Conclusions

This systematic review revealed gastrodin is effective and safe in the treatment of migraine.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=197094, identifier: CRD42020197094.

Research Insights

Gastrodia→Improved Migraine Treatment Effectiveness
The meta-analysis showed that gastrodin was significantly effective in treating migraine (RR = 1.21, 95%CI = [1.17, 1.27])
Effect
Beneficial
Effect size
Moderate
Gastrodia→Reduced Cerebral Blood Flow Velocity
slowing average arterial cerebral blood flow velocity (SMD = -3.19, 95% CI = [-5.21, -1.17])
Effect
Beneficial
Effect size
Large
Gastrodia→Reduced Migraine Attack Duration
shortening the duration of migraine attack (SMD = -1.64, 95% CI = [-2.35, -0.93])
Effect
Beneficial
Effect size
Large
Gastrodia→Reduced Migraine Attack Frequency
reducing the frequency of migraine attack (SMD = -2.77, 95% CI = [-3.92, -1.62])
Effect
Beneficial
Effect size
Large
Gastrodia→Reduced Pain Intensity
reducing the pain degree (MD = -1.65, 95% CI = [-2.28, -1.02])
Effect
Beneficial
Effect size
Moderate

Adverse Events Reported

Gastrodia→Overall tolerability
as well as being safe
Finding
Reported