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Effects of a sea buckthorn oil spray emulsion on dry eye.

  • 2018-11-26
  • Contact lens & anterior eye : the journal of the British Contact Lens Association 42(4)
    • Petra Larmo
    • Riikka Järvinen
    • Jarmo Laihia
    • Eliisa Löyttyniemi
    • Laura Maavirta
    • Baoru Yang
    • Heikki Kallio
    • Minna Sandberg-Lall

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 40
Population
Adults (25-70 years) with Ocular Surface Disease Index (OSDI) ≥20 and moderate or severe dryness, burning or grittiness of the eyes
Methods
Randomized controlled study; SB spray used on closed eyelids; includes three parts: part one (n=2) four times in one day; part two (n=10) SB vs reference spray for nine days; part three (n=40) SB spray vs untreated control for 1.5 months
Duration
1.5 months

Purpose

To investigate the effects of a sea buckthorn oil and sodium hyaluronate-containing eyelid spray emulsion (SB spray) on dry eye.

Methods

A randomized controlled study was carried out. Adults (25-70 years) with Ocular Surface Disease Index (OSDI) ≥20 and moderate or severe dryness, burning or grittiness of the eyes were included. In study part one (n = 2), SB spray was used on both closed eyelids four times in one day. In part two (n = 10), SB spray was used on one randomized eyelid, and a commercial reference spray on the other for nine days. In part three (n = 40), eyes were randomized to one eye receiving SB spray and an untreated control for 1.5 months. Dry eye tests were carried out at baseline, during, and at the end of each study section. Symptoms were recorded in questionnaires and daily logs.

Results

In part one, the SB spray was well tolerated. In part two, OSDI decreased significantly (P = 0.022) in the SB spray eye compared to the reference spray, indicating a beneficial effect on symptoms. In part three, OSDI in the SB spray eye decreased significantly compared to the untreated control (P = 0.0007). The scores for dryness at the study end were lower in the SB spray eye compared to control (P = 0.0070). Symptom sums and frequencies of dryness (sum P = 0.0046, frequency P = 0.0016) and watering (sum P = 0.0003, frequency P = 0.013) in the daily logs were lower in the eye treated with SB spray.

Conclusions

SB spray on closed eyelids relieved the symptoms of dry eye.

Research Insights

  • Sea Buckthorn→Improved Ocular Surface Disease Index

    In part three, OSDI in the SB spray eye decreased significantly compared to the untreated control (P=0.0007).

    Effect
    Beneficial
    Effect size
    Moderate
  • Sea Buckthorn→Reduced Dryness

    The scores for dryness at the study end were lower in the SB spray eye compared to control (P=0.0070).

    Effect
    Beneficial
    Effect size
    Moderate
  • Sea Buckthorn→Reduced Dryness Frequency

    Symptom sums and frequencies of dryness (sum P=0.0046, frequency P=0.0016) and watering (sum P=0.0003, frequency P=0.013) in the daily logs were lower in the eye treated with SB spray.

    Effect
    Beneficial
    Effect size
    Moderate
  • Sea Buckthorn→Reduced Watering Frequency

    Symptom sums and frequencies of dryness (sum P=0.0046, frequency P=0.0016) and watering (sum P=0.0003, frequency P=0.013) in the daily logs were lower in the eye treated with SB spray.

    Effect
    Beneficial
    Effect size
    Moderate
  • Sea Buckthorn→Reduced Watery Stools

    Symptom sums and frequencies of dryness (sum P=0.0046, frequency P=0.0016) and watering (sum P=0.0003, frequency P=0.013) in the daily logs were lower in the eye treated with SB spray.

    Effect
    Beneficial
    Effect size
    Moderate

Adverse Events Reported

  • Sea Buckthorn→Overall tolerability

    In part one, the SB spray was well tolerated.

    Finding
    Reported
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