Bacillus coagulans and its applications in medicine.

2019-07-10
Beneficial microbes 10(6)
- Y Mu
- Y Cong

PubMed: 31203635
DOI: 10.3920/bm2019.0016

Study Design

Type: Review

Rigorous Journal

Bacillus coagulans is a probiotic bacterium that produces spores. Due to its excellent stability, it has been widely used in medicine, food and chemical industry. Recent studies have shown that B. coagulans has therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis via modulation of the microbiota composition, host immunity and metabolism. Additionally, toxicological experiments and a large number of clinical observations have showed that B. coagulans is safe and has no effect of mutagenicity, teratogenicity or genotoxicity. This review summarises the latest advances associated with B. coagulans, from its biological features, probable action mechanisms, toxicity, and medical applications.

Research Insights

Bacillus coagulans→Improved Bowel Movement Frequency
Recent studies have shown that B. coagulans has therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis via modulation of the microbiota composition, host immunity and metabolism.
Effect
Beneficial
Effect size
Small
Bacillus coagulans→Improved Irritable Bowel Syndrome Symptoms
Recent studies have shown that B. coagulans has therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis via modulation of the microbiota composition, host immunity and metabolism.
Effect
Beneficial
Effect size
Small
Bacillus coagulans→Reduced Acute Diarrhea
Recent studies have shown that B. coagulans has therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis via modulation of the microbiota composition, host immunity and metabolism.
Effect
Beneficial
Effect size
Small
Bacillus coagulans→Reduced Colitis
Recent studies have shown that B. coagulans has therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis via modulation of the microbiota composition, host immunity and metabolism.
Effect
Beneficial
Effect size
Small
Bacillus coagulans→Reduced Diarrhea Rate
Recent studies have shown that B. coagulans has therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis via modulation of the microbiota composition, host immunity and metabolism.
Effect
Beneficial
Effect size
Small

Adverse Events Reported

Bacillus coagulans→Overall tolerability
toxicological experiments and a large number of clinical observations have showed that B. coagulans is safe and has no effect of mutagenicity, teratogenicity or genotoxicity
Finding
Reported