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Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study.

  • 2018-05-09
  • Nutrients 10(5)
    • Mikiko Watanabe
    • Elena Gangitano
    • Davide Francomano
    • Eliana Addessi
    • Raffaella Toscano
    • Daniela Costantini
    • Dario Tuccinardi
    • Stefania Mariani
    • Sabrina Basciani
    • Giovanni Spera
    • Lucio Gnessi
    • Carla Lubrano

Study Design

Type
Randomized Controlled Trial (RCT)
Population
22 obese female patients with insulin resistance
Methods
randomized 1:1 to behavioral therapy alone or behavioral therapy and mangosteen
Blinding
Open-label
Duration
26 weeks
  • Rigorous Journal
There is a widely acknowledged association between insulin resistance and obesity/type 2 diabetes (T2DM), and insulin sensitizing treatments have proved effective in preventing diabetes and inducing weight loss. Obesity and T2DM are also associated with increased inflammation. Mangosteen is a tropical tree, whose fruits—known for their antioxidant properties—have been recently suggested having a possible further role in the treatment of obesity and T2DM. The objective of this pilot study has been to evaluate safety and efficacy of treatment with mangosteen extract on insulin resistance, weight management, and inflammatory status in obese female patients with insulin resistance. Twenty-two patients were randomized 1:1 to behavioral therapy alone or behavioral therapy and mangosteen and 20 completed the 26-week study. The mangosteen group reported a significant improvement in insulin sensitivity (homeostatic model assessment-insulin resistance, HOMA-IR −53.22% vs. −15.23%, p = 0.004), and no side effect attributable to treatment was reported. Given the positive preliminary results we report and the excellent safety profile, we suggest a possible supplementary role of mangosteen extracts in the treatment of obesity, insulin resistance, and inflammation.

Research Insights

  • Mangosteen→Improved Insulin Sensitivity

    The mangosteen group reported a significant improvement in insulin sensitivity (homeostatic model assessment-insulin resistance, HOMA-IR −53.22% vs. −15.23%, p = 0.004)

    Effect
    Beneficial
    Effect size
    Large

Adverse Events Reported

  • Mangosteen→Overall tolerability

    no side effect attributable to treatment was reported

    Finding
    Reported
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