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Sexual safety and efficacy of a pollen extract and teupolioside-based supplement in men with benign prostatic hyperplasia: a prospective observational study.

  • 2025-09-30
  • Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 97(3)
    • Matteo Vittori
    • Valerio Iacovelli
    • Marco Carilli
    • Carlo Brocca
    • Michele Antonucci
    • Filomena Petta
    • Beatrice Filippi
    • Giulia Di Giovanni
    • Marta Signoretti
    • Francesco Maiorino
    • Andrea Benedetto Galosi
    • Pierluigi Bove

Study Design

Type
Observational
Sample size
n = 25
Population
25 men with moderate LUTS due to BPH
Methods
prospective, single-arm observational study; daily pollen extract and teupolioside supplementation for 90 days
Blinding
Open-label
Duration
90 days

Background

Benign prostatic hyperplasia (BPH) is a common age-related condition that often results in lower urinary tract symptoms (LUTS), reduced quality of life, and sexual dysfunction. Conventional pharmacotherapies, while effective, are frequently associated with adverse effects on sexual and ejaculatory function. This study evaluated the sexual safety and clinical efficacy of a dietary supplement containing pollen extract and teupolioside, in men with BPH.

Methods

In this prospective, single-arm observational study, 25 men with moderate LUTS due to BPH received daily pollen extract and teupolioside supplementation for 90 days. The primary endpoints were sexual function (International Index of Erectile Function, IIEF-5), ejaculatory function (Male Sexual Health Questionnaire-Ejaculatory Dysfunction, MSHQ-EjD), quality of life (IPSS-QoL), and patient global impression of improvement (PGI-I). Secondary endpoints included changes in urinary flow (Qmax) and LUTS severity (International Prostate Symptom Score, IPSS). Assessments were conducted at baseline, 1 month, and 3 months.

Results

Sexual and ejaculatory functions remained stable over the treatment period, with no statistically significant deterioration observed. QoL improved significantly by the 3-month mark (IPSS-QoL median score reduced from 3 to 2; p<0.008), and PGI-I scores reflected high patient satisfaction (median 2, IQR 1). Qmax significantly increased from 12.4 mL/s at baseline to 15.5 mL/s at 3 months (p<0.001), and IPSS scores significantly declined from 11 to 8 (p<0.008), indicating improved urinary function.

Conclusions

The pollen extract and teupolioside supplementation was well tolerated and associated with improved QoL and urinary outcomes, without compromising sexual or ejaculatory function. These findings support its potential as a non-pharmacologic adjunct in the management of BPH, particularly in patients concerned about sexual side effects. Further randomized controlled studies are warranted to confirm these results.

Research Insights

Adverse Events Reported

  • Flower Pollen→Overall tolerability

    The pollen extract and teupolioside supplementation was well tolerated

    Finding
    Reported
  • Flower Pollen→ejaculatory dysfunction

    Sexual and ejaculatory functions remained stable over the treatment period, with no statistically significant deterioration observed.

    Finding
    Reported
    Significant
    No
  • Flower Pollen→erectile dysfunction

    Sexual and ejaculatory functions remained stable over the treatment period, with no statistically significant deterioration observed.

    Finding
    Reported
    Significant
    No
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