Systematic review with meta-analysis: Saccharomyces boulardii for treating acute gastroenteritis in children-a 2020 update.

2020-02-13
Alimentary pharmacology & therapeutics 51(7)
- Hania Szajewska
- Maciej Kołodziej
- Bartłomiej M Zalewski

PubMed: 32056266
DOI: 10.1111/apt.15659

Study Design

Type: Meta-Analysis
Sample size: n = 3,450
Population: children with acute gastroenteritis
Methods: Systematic review of RCTs comparing Saccharomyces boulardii with placebo or no treatment; databases searched from inception to December 2019

Rigorous Journal

Background

There is still controversy with regard to the efficacy of individual probiotic strains for the management of acute gastroenteritis.

Aim

To update evidence on use of Saccharomyces boulardii for treating acute gastroenteritis in children.

Methods

The Cochrane Library, MEDLINE and EMBASE databases were searched from inception to December 2019 for randomised controlled trials (RCTs) that compared use of S boulardii with no S boulardii (defined as placebo or no treatment). The grey literature was searched through Google search. Authors of the original papers and S boulardii manufacturers were contacted for additional data.

Results

Twenty-nine RCTs (among them, 20 newly identified trials) were included. Only 38% of trials adequately generated their randomisation sequence, only 17% adequately concealed allocation and only one trial adequately blinded participants, study personnel and outcome assessors. However, 83% provided complete outcome data. None of the trials evaluated the effect of S boulardii on stool volume. Compared with placebo or no treatment, S boulardii use reduced the duration of diarrhoea (23 RCTs, n = 3450, mean difference -1.06 day, 95% CI -1.32 to -0.79; high heterogeneity [I² = 90%]) (very low quality of evidence). S boulardii use was also associated with a reduced duration of hospitalisation (8 RCTs, n = 999, mean difference -0.85 day, 95% CI -1.35 to -0.34; I² = 91%) (very low quality of evidence). S boulardii reduced the risk of diarrhoea on day 2 to day 7 (low quality of evidence).

Conclusions

In children with acute gastroenteritis, low- to very low-quality evidence suggests that S boulardii confers a benefit for several diarrhoeal outcomes.

Research Insights

saccharomyces boulardii→Reduced Diarrhea Rate
S boulardii reduced the risk of diarrhoea on day 2 to day 7 (low quality of evidence).
Effect
Beneficial
Effect size
Small
saccharomyces boulardii→Reduced Hospitalization Duration
S boulardii use was also associated with a reduced duration of hospitalisation (8 RCTs, n = 999, mean difference -0.85 day, 95% CI -1.35 to -0.34; I2 = 91%) (very low quality of evidence).
Effect
Beneficial
Effect size
Moderate

Adverse Events Reported

saccharomyces boulardii→Overall tolerability
None of the trials evaluated the effect of S boulardii on stool volume.
Finding
Reported