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The role of Bromelain and Liposomal Vitamin C in the treatment of chronic venous disease.

  • 2025-05
  • VASA. Zeitschrift fur Gefasskrankheiten 54(3)
    • Giacomo Buso
    • Paolo Santini
    • Francesca Ghirardini
    • Francesca Cannavacciuolo
    • Adriana Visonà
    • Beniamino Zalunardo
    • Roberto Pola
    • Romeo Martini

Study Design

Type
Systematic Review
Methods
systematic review of the literature, comprehensive search yielded nine studies, two on bromelain and seven on vitamin C
Chronic venous disease (CVD) is a prevalent condition leading to significant morbidity and affecting quality of life. Among conservative treatment strategies, venoactive drugs are often recommended by major guidelines for the management of CVD. Bromelain and vitamin C are now emerging as promising options in the management of several chronic diseases owing to their anti-inflammatory, immunoregulatory, and antioxidant properties, though evidence remains scarce in this setting. This systematic review of the literature, endorsed by the Italian Society of Angiology and Vascular Medicine (Societa Italiana di Angiologia e Patologia Vascolare, SIAPAV), aims to evaluate the efficacy and safety of these compounds in the treatment of CVD. A comprehensive search yielded nine studies, two on bromelain and seven on vitamin C. No studies have evaluated the effects of bromelain and vitamin C alone or in combination, whereas both molecules were administered in combination with other nutritional supplements. Overall, CVD-related symptoms and edema seem to improve with dietary supplement containing these two compounds, with no major safety issues reported. Bromelain and vitamin C may thus represent attractive options in the management of patients with symptomatic CVD and/or presence of venous edema, provided optimal conservative treatment is in place. Dedicated clinical studies are needed to clarify the efficacy and safety of a combination of these molecules in CVD management.

Research Insights

  • Bromelain→Improved CVD-Related Symptom

    Overall, CVD-related symptoms and edema seem to improve with dietary supplement containing these two compounds

    Effect
    Beneficial
    Effect size
    Small
  • Bromelain→Reduced Cardiovascular Disease Symptom

    Overall, CVD-related symptoms and edema seem to improve with dietary supplement containing these two compounds, with no major safety issues reported.

    Effect
    Beneficial
    Effect size
    Small
  • Bromelain→Reduced Edema

    CVD-related symptoms and edema seem to improve with dietary supplement containing these two compounds

    Effect
    Beneficial
    Effect size
    Small

Adverse Events Reported

  • Bromelain→Overall tolerability

    no major safety issues reported

    Finding
    Reported
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