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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Acetyl-Carnitine and Improved Mini-Mental State Examination Score

Doses used in studies

g/day: 1.5 (median 1.5, IQR 1.5–1.5) — 1 study

Time to effect

Median: 4.3 months · IQR 3.7 months–5 months · Range 3 months–5.6 months — Reported in 2 of 2 studies

2 of 2 papers

Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial.
- 2022-10
- RCT · n = 92
- Current pharmaceutical design 28(38)
- - Giulia Malaguarnera
  - Vito Emanuele Catania
  - Gaetano Bertino
  - Laura Maria Chisari
  - Maria Castorina
  - Claudia Bonfiglio
  - Omar Cauli
  - Michele Malaguarnera
- PubMed: 36043711
- DOI: 10.2174/1381612828666220830092815
4 Insights on
- Improved Mini-Mental State Examination Score
- High evidence
- Clinical
increase in Mini-Mental state (MMSE) p < 0.0001; ALCAR group vs. placebo group showed an increase in MMSE score (p < 0.001)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
1.5 g BID
Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial.
- 2024-06-14
- RCT · n = 119
- Medicine 103(24)
- - Wankiun Lee
  - Manho Kim
- PubMed: 38875437
- DOI: 10.1097/md.0000000000038067
3 Insights on
- Improved Mini-Mental State Examination Score
- High evidence
- Large Human Trial
- Clinical
In the DA + DG group, it decreased by 2.17% at the 12th week and by 5.71% at the 24th week.
Effect
Neutral
Effect size
Small
Significant
No
Dose
not stated