Beta-Alanine and Increased Carnosine Level

• Efficacy of 12 weeks oral beta-alanine supplementation in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled trial.

  • 2022-08-17
  • RCT · n = 40
  • Journal of cachexia, sarcopenia and muscle 13(5)
  • • Jana De Brandt
    • Wim Derave
    • Frank Vandenabeele
    • Pascal Pomiès
    • Laura Blancquaert
    • Charly Keytsman
    • Marina S Barusso-Grüninger
    • Fabiano F de Lima
    • Maurice Hayot
    • Martijn A Spruit
    • Chris Burtin

  • PubMed: 35977911
  • DOI: 10.1002/jcsm.13048

  11 Insights on

  • Increased Carnosine Level

  • High evidence
  • Clinical

  Beta-alanine supplementation increased muscle carnosine in comparison with PL in patients with COPD (mean difference [95% confidence interval]; +2.82 [1.49-4.14] mmol/kg wet weight; P < 0.001).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  3.2 g/day

• Individual Participant Data Meta-Analysis Provides No Evidence of Intervention Response Variation in Individuals Supplementing With Beta-Alanine.

  • 2021-07-01
  • Meta-Analysis
  • International journal of sport nutrition and exercise metabolism 31(4)
  • • Gabriel Perri Esteves
    • Paul Swinton
    • Craig Sale
    • Ruth M James
    • Guilherme Giannini Artioli
    • Hamilton Roschel
    • Bruno Gualano
    • Bryan Saunders
    • Eimear Dolan

  • PubMed: 34098531
  • DOI: 10.1123/ijsnem.2021-0038

  2 Insights on

  • Increased Carnosine Level

  • High evidence

  and muscle carnosine (18.1, 95% CrI [14.5, 21.9] mmol/kg DM)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes