Carnosine and Improved Bilateral Calf Raise Endurance

• Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial.

  • 2026-06-17
  • RCT · n = 299
  • Journal of the International Society of Sports Nutrition 23(1)
  • • Timothy E O'Toole
    • Christopher J Wingard
    • Sonja K Bariess
    • Catherine E Crandell
    • Alok R Amraotkar
    • Hong Gao
    • Aruni Bhatnagar

  • PubMed: 42308284
  • DOI: 10.1080/15502783.2026.2679716

  7 Insights on

  • Improved Bilateral Calf Raise Endurance

  • High evidence
  • Large Human Trial

  At Visit-3 we observed a statistically significant (p = 0.018) increase in the calf raise measure (number of bi-lateral flexions to exhaustion) for those in the carnosine supplementation group younger than 40 years of age.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  2 g per day