Glutathione and Improved Non-Motor Symptoms

• The role of N-acetylcysteine and glutathione in the management of Parkinson's disease: a systematic review of oxidative biomarkers and clinical outcomes.

  • 2026-03-24
  • Systematic Review · n = 196
  • Amino acids 58(1)
  • • Imran Mohammed
    • Yasimin Nankya
    • U Teng Hong
    • Amy Kan
    • Alya Masoud Abdelhafid
    • Gladys O Latunde-Dada

  • PubMed: 41874704
  • DOI: 10.1007/s00726-026-03513-5

  1 Insight on

  • Improved Non-Motor Symptoms

  • High evidence
  • Clinical

  NAC improved both motor and non-motor symptoms and significantly increased GSH/GSSG ratios, GSH levels in the CSF, and DAT binding.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  No