Glycine and Reduced Tumor Downstaging

• Plasma serine and glycine in relation to clinical outcomes following neoadjuvant radiotherapy for rectal cancer.

  • 2026-07
  • Observational · n = 288
  • Clinical and translational radiation oncology 59
  • • Nienke R K Zwart
    • Per Magne Ueland
    • Adrian McCann
    • Jill A McKay
    • Heidi Rütten
    • Johannes A Bogers
    • Johannes H W de Wilt
    • Ellen Kampman
    • Dieuwertje E Kok

  • PubMed: 42005714
  • DOI: 10.1016/j.ctro.2026.101159

  1 Insight on

  • Reduced Tumor Downstaging

  • High evidence

  Serine, glycine, and their ratio were not associated with tumour downstaging.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No