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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Arginine and Improved Lubrication

Doses used in studies

mg/day: 2,000 (median 2,000, IQR 2,000–2,000) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityReported
with minimal side effects observed
from: Effect of l-arginine compared to placebo on sexual function in women with major depressive

1 of 1 paper

Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial.
- 2024-05-14
- RCT
- BMC psychiatry 24(1)
- - Pouria Torkaman
  - Azadeh Mazaheri Meybodi
  - Ali Kheradmand
  - Shiva Eiliaei
  - Maria Tavakoli Ardakani
- PubMed: 38745327
- DOI: 10.1186/s12888-024-05781-5
4 Insights on
- Improved Lubrication
- High evidence
- Clinical
Based on the FSFI questionnaire, they had improvement in some domains, including the lubrication index and orgasm index, which significantly changed in the eighth week compared to the baseline (P-value < 0.05). However, these two indicators did not change statistically significantly compared to the placebo group.
Effect
Neutral
Effect size
Small
Significant
No
Dose
1 gram twice daily