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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Arginine and Improved Quality of Life

Doses used in studies

g/day: 5 (median 5, IQR 5–5) — 1 study

Time to effect

Median: 3.9 months · IQR 11.8 weeks–5 months · Range 7 weeks–6.1 months — Reported in 2 of 2 studies

2 of 2 papers

L-arginine vs. L-glutamine oral suspensions for radiation-induced oral mucositis: a triple-blind randomized trial.
- 2025-07-03
- RCT · n = 23
- Journal of cancer research and clinical oncology 151(7)
- - Fatma E A Hassanein
  - Christine Mikhail
  - Sarah Elkot
  - Asmaa Abou-Bakr
- PubMed: 40603739
- DOI: 10.1007/s00432-025-06213-x
4 Insights on
- Improved Quality of Life
- High evidence
- Clinical
OHIP-14 scores improved significantly in the arginine and glutamine groups at weeks 5 and 7 (p < 0.001).
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
5 g
Efficacy Of Combined Nutritional And Pharmacological Interventions In PCOS: A Six Month Randomized Controlled Trial.
- 2025-09-30
- RCT
- Naunyn-Schmiedeberg's archives of pharmacology 399(3)
- - Musarrat Zahra
  - Mohsin Shah
  - Fiza Iqbal
  - Tariq Zubair
  - Rozina Habib
  - Fatima Zulfiqar
- PubMed: 41026176
- DOI: 10.1007/s00210-025-04626-6
3 Insights on
- Improved Quality of Life
- High evidence
- Clinical
Quality of life improved significantly in both arms, with greater gains in the combination group (p = .037, η2 = .071).
Effect
Beneficial
Effect size
Small
Significant
Yes