Combination Therapy with Pyridoxine and Arginine Supplementations along with a Lysine-Restricted Diet in Individuals with Pyridoxine-Dependent Epilepsy: A Comprehensive Systematic Review.
- 2025-08
- Review
- Current developments in nutrition 9(8)
- Ali Jafari
- Mohammad Mehdi Abbasi
- Hamid Abbasi
- Sama Rahnemayan
- Farnush Bakhshimoghaddam
- Saeid Doaei
- PubMed: 40800672
- DOI: 10.1016/j.cdnut.2025.107504
- Low evidence
- Clinical
pyridoxine monotherapy is a highly effective first-line treatment in PDE that improves seizure control with minimal cognitive decline.
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes