L-ornithine supplementation in periodontitis treatment yields greater benefits than L-arginine after one year: Part II of a randomized controlled pilot study.
- 2025-09
- RCT · n = 75
- Complementary therapies in medicine 92
- Viktoriya I Shynkevych
- Svitlana V Kolomiiets
- Kristina O Udaltsova
- Igor P Kaidashev
- PubMed: 40614877
- DOI: 10.1016/j.ctim.2025.103202
- High evidence
- Clinical
L-arginine resulted in increased density of CD68+ macrophages and elevated CD68+/CD163+ ratio compared to the PMPR and L-ornithine; CI [0.41-0.63], p = 0.009, CI [1.45-2.72], p < 0.0001
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes