L-Arginine and Increased L-arginine Level

Doses used in studies

g/kg/day: 0.1–0.2 (median 0.15, IQR 0.1–0.2) — 1 study

Time to effect

Median: 8.4 weeks · IQR 6.2 weeks–10.6 weeks · Range 4 weeks–3 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityNo significant difference
No significant differences in side effects were observed between the two groups, indicating that L-arginine is safe for these patients.
from: Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with
side effectsNo significant difference
No significant differences in side effects were observed between the two groups, indicating that L-arginine is safe for these patients.
from: Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with

2 of 2 papers

Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial.
- 2025-06-17
- RCT · n = 50
- Paediatric drugs 27(5)
- - Dalia A Gomaa
  - Sahar M El-Haggar
  - Mohamed R El-Shanshory
  - Osama El-Razaky
  - Dalia R El-Afify
- PubMed: 40526198
- DOI: 10.1007/s40272-025-00701-w
7 Insights on
- Increased L-arginine Level
- High evidence
- Clinical
significantly higher ... LA
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
0.1-0.2 g/kg/day
Effects of l-Arginine Plus Vitamin C Supplementation on l-Arginine Metabolism in Adults with Long COVID: Secondary Analysis of a Randomized Clinical Trial.
- 2023-03-07
- RCT
- International journal of molecular sciences 24(6)
- - Riccardo Calvani
  - Jacopo Gervasoni
  - Anna Picca
  - Francesca Ciciarello
  - Vincenzo Galluzzo
  - Hélio José Coelho-Júnior
  - Clara Di Mario
  - Elisa Gremese
  - Sara Lomuscio
  - Anna Maria Paglionico
  - Lavinia Santucci
  - Barbara Tolusso
  - Andrea Urbani
  - Federico Marini
  - Emanuele Marzetti
  - Francesco Landi
  - Matteo Tosato
- PubMed: 36982151
- DOI: 10.3390/ijms24065078
2 Insights on
- Increased L-arginine Level
- High evidence
- Rigorous Journal
- Clinical
After 28 days of l-arginine plus vitamin C supplementation, serum l-arginine concentrations and l-arginine/ADMA increased significantly compared with placebo.
Effect
Beneficial
Effect size
Small
Significant
Yes

L-Arginine and Increased L-arginine Level

Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial.

Effects of l-Arginine Plus Vitamin C Supplementation on l-Arginine Metabolism in Adults with Long COVID: Secondary Analysis of a Randomized Clinical Trial.