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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Arginine and Increased Nitric Oxide Level

Doses used in studies

g/day: 3.2–9.6 (median 6.4, IQR 3.2–9.6) — 1 study
g/kg/day: 0.1–0.2 (median 0.15, IQR 0.1–0.2) — 1 study

Time to effect

Median: 6.7 weeks · IQR 3.6 weeks–9.8 weeks · Range 4 days–3 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityNo significant difference
No significant differences in side effects were observed between the two groups, indicating that L-arginine is safe for these patients.
from: Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with
side effectsNo significant difference
No significant differences in side effects were observed between the two groups, indicating that L-arginine is safe for these patients.
from: Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with

2 of 2 papersPopulation:

Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study.
- 2026-01-01
- RCT
- International journal of sport nutrition and exercise metabolism 36(1)
- - Cezimar Correia Borges
  - Weder Alves da Silva
  - Alberto Souza de Sá Filho
  - Vicente Aprigliano
  - Pedro Augusto Inacio
  - Marina Silveira
  - Gerson Ferrari
- PubMed: 41248623
- DOI: 10.1123/ijsnem.2025-0125
10 Insights on
- Increased Nitric Oxide Level
- High evidence
- Athletes
Plasma NO levels did not differ between conditions (p = .522)
Effect
Neutral
Effect size
Small
Significant
No
Dose
3.2-9.6 g/day
Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial.
- 2025-06-17
- RCT · n = 50
- Paediatric drugs 27(5)
- - Dalia A Gomaa
  - Sahar M El-Haggar
  - Mohamed R El-Shanshory
  - Osama El-Razaky
  - Dalia R El-Afify
- PubMed: 40526198
- DOI: 10.1007/s40272-025-00701-w
7 Insights on
- Increased Nitric Oxide Level
- High evidence
- Clinical
significantly higher NO
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
0.1-0.2 g/kg/day