L-Arginine and Increased Spontaneous Stone Expulsion Rate

Doses used in studies

mg/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 1 study

1 of 1 paper

L-arginine role for stone lower ureter: A randomized controlled trial.

2025-06-11
RCT · n = 162
Urolithiasis 53(1)
- Ahmed Mahmoud Mohammed Ahmed Elsherief
- Ahmed Mahmoud Riyad
- Emad Abdellah Ali
- Amr Alam-Eldin Ahmed
- Hassan Ali Gad
- Ahmed Mamdouh Abd Elhameid

PubMed: 40498114
DOI: 10.1007/s00240-025-01768-3

7 Insights on

Increased Spontaneous Stone Expulsion Rate

High evidence
Large Human Trial
Clinical

Spontaneous stone expulsion rates (SER) in the control, L-arginine, and tamsulosin groups were 6 (11.8%), 48 (94.1%), and 16 (31.4%), respectively (p < 0.001).

Effect: Beneficial
Effect size: Large
Significant: Yes
Dose: 1000 mg once daily