L-Arginine and Preserved Skeletal Muscle Index

• An open-label, randomized, controlled trial on the benefit of β-hydroxy-β-methyl butyrate, l-arginine, l-glutamine combination beverages and locomotion training as supportive care for the treatment of unresectable hepatocellular carcinoma using lenvatinib: A pilot study (HELLO study).

  • 2025-02
  • RCT · n = 20
  • Clinical nutrition ESPEN 65
  • • Atsushi Naganuma
    • Fujio Makita
    • Rie Sugimoto
    • Masahiro Kikuchi
    • Kiyoshi Furuta
    • Satoru Iwamoto
    • Ryotaro Sakamori
    • Hirotaka Kouno
    • Keisuke Ario
    • Hiroshi Yatsuhashi

  • PubMed: 39675424
  • DOI: 10.1016/j.clnesp.2024.12.005

  1 Insight on

  • Preserved Skeletal Muscle Index

  • High evidence
  • Clinical

  a slight retention of L3-SMI values in the intervention group compared with that in the control group was observed (96.5 % vs. 89.9 %, p = 0.407).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  No