L-Arginine and Reduced Analgesic Use

• The efficacy of oral L-arginine therapy for the treatment of vaso-occlusive pain episodes in children with sickle cell disease.

  • 2025-08-27
  • RCT · n = 20
  • Pediatric hematology and oncology 42(6-7)
  • • Aya Mohamed Abd Elglil
    • Mohamed Ramadan El-Shanshory
    • Hamed Mohamed Elsharkawy
    • Walaa Arafa Keshk
    • Nahed M Hablas
    • Lamia M Morad

  • PubMed: 40862485
  • DOI: 10.1080/08880018.2025.2549365

  4 Insights on

  • Reduced Analgesic Use

  • High evidence
  • Clinical

  total analgesic use (p-value <0.001)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  100 mg/kg/dose three times/day for 15 doses or until discharge