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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Arginine and Reduced Blood Lactate

Doses used in studies

g/day: 3.2–9.6 (median 7.2, IQR 4.4–9.2) — 2 studies

Time to effect

Median: 6 days · IQR 5 days–7 days · Range 4 days–8 days — Reported in 2 of 2 studies

2 of 2 papers

Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study.
- 2026-01-01
- RCT
- International journal of sport nutrition and exercise metabolism 36(1)
- - Cezimar Correia Borges
  - Weder Alves da Silva
  - Alberto Souza de Sá Filho
  - Vicente Aprigliano
  - Pedro Augusto Inacio
  - Marina Silveira
  - Gerson Ferrari
- PubMed: 41248623
- DOI: 10.1123/ijsnem.2025-0125
10 Insights on
- Reduced Blood Lactate
- High evidence
- Athletes
Blood lactate concentrations rose after exercise in both groups, with a nonsignificant value in the ARG condition (p = .09 at 9-min postexercise)
Effect
Neutral
Effect size
Small
Significant
No
Dose
3.2-9.6 g/day
Eight Days of L-Citrulline or L-Arginine Supplementation Did Not Improve 200-m and 100-m Swimming Time Trials.
- 2022-04-07
- RCT · n = 5
- International journal of environmental research and public health 19(8)
- - Ozcan Esen
  - Mustafa Can Eser
  - Mekki Abdioglu
  - Daniela Benesova
  - Tomasz Gabrys
  - Raci Karayigit
- PubMed: 35457330
- DOI: 10.3390/ijerph19084462
4 Insights on
- Reduced Blood Lactate
- High evidence
- Athletes
There was a main effect of time on BLa concentration (p < 0.001), but no trial × group (p = 0.243) and trial × lactate × group interaction effect (p = 0.276) was present.
Effect
Neutral
Effect size
Small
Significant
No
Dose
8 gr/day