Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Arginine and Reduced Depression Severity

Doses used in studies

mg/day: 2,000 (median 2,000, IQR 2,000–2,000) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityReported
with minimal side effects observed
from: Effect of l-arginine compared to placebo on sexual function in women with major depressive

1 of 1 paper

Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial.
- 2024-05-14
- RCT
- BMC psychiatry 24(1)
- - Pouria Torkaman
  - Azadeh Mazaheri Meybodi
  - Ali Kheradmand
  - Shiva Eiliaei
  - Maria Tavakoli Ardakani
- PubMed: 38745327
- DOI: 10.1186/s12888-024-05781-5
4 Insights on
- Reduced Depression Severity
- High evidence
- Clinical
A decrease in the severity of depression was observed in all patients, which was determined due to Hamilton's questionnaire (P-value < 0.001).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
1 gram twice daily