L-Arginine and Reduced Lactate Level

• A pharmacodynamic study of rapid lactate metabolic modulation by intravenous L-arginine in brain metastases.

  • 2026-05-28
  • Clinical Trial
  • Frontiers in oncology 16
  • • Xueping Liu
    • Guobo Du
    • Nai Mu
    • Lang He

  • PubMed: 42294329
  • DOI: 10.3389/fonc.2026.1845249

  1 Insight on

  • Reduced Lactate Level

  • Moderate evidence
  • Clinical

  The pooled L-arginine group showed significantly greater lactate reduction at T3 compared with controls (median ΔLac_T3: -1.09 vs. 0.00, p = 0.0012). Lactate reduction was most prominent and consistent in the 30 g group, with a peak reduction of 63.5% at 30 minutes (ρ = -0.753, p < 0.001).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  10 g, 20 g, or 30 g intravenous