L-Arginine and Reduced Pain Severity

• Antioxidant supplementation for sickle cell disease.

  • 2024-05-22
  • Meta-Analysis · n = 1,609
  • The Cochrane database of systematic reviews 2024(5)
  • • Abiola B Bolarinwa
    • Olabisi Oduwole
    • Joseph Okebe
    • Ann A Ogbenna
    • Oluwakemi E Otokiti
    • Adejoke T Olatinwo

  • PubMed: 38775255
  • DOI: 10.1002/14651858.cd013590.pub2

  2 Insights on

  • Reduced Pain Severity

  • High evidence
  • Clinical

  L-arginine may be better than placebo at reducing the severity of pain (MD -1.41, 95% CI -1.65 to -1.18; 2 studies, 125 participants; low-certainty evidence).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• L-arginine vs. L-glutamine oral suspensions for radiation-induced oral mucositis: a triple-blind randomized trial.

  • 2025-07-03
  • RCT · n = 23
  • Journal of cancer research and clinical oncology 151(7)
  • • Fatma E A Hassanein
    • Christine Mikhail
    • Sarah Elkot
    • Asmaa Abou-Bakr

  • PubMed: 40603739
  • DOI: 10.1007/s00432-025-06213-x

  4 Insights on

  • Reduced Pain Severity

  • High evidence
  • Clinical

  Pain-VAS scores at weeks 5 and 7 were significantly lower in the arginine and glutamine groups compared to maltodextrin (p = 0.004 and p < 0.001, respectively).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  5 g