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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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L-Arginine and Reduced Systolic Blood Pressure

Research synthesisLow evidenceMixed effect size4 studies · 2 beneficial · 2 neutral · 0 harmful

Across 4 studies, 2 reported beneficial effects of L-arginine on reducing systolic blood pressure, while 2 found neutral results. The beneficial effects ranged from small to large, with a moderate effect observed in one meta-analysis (SBP reduction of -5.64 mmHg) among pregnant women. The most-studied populations were pregnant women and older adults, but doses and forms were poorly reported, limiting convergence on an effective dose range.

  • Studied populations: pregnant women, high-risk pregnancies, middle-aged and elderly individuals

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. No form data were extracted, and doses were not consistently reported, making it unclear which formulation or dose drives the effect.

Generated Jun 11, 2026
Doses used in studies
  • g/day: 3 (median 3, IQR 3–3) — 1 study
4 of 4 papers
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