L-Arginine and Reduced Time to Cessation of Oxygen Support

• The effect of l-arginine supplementation on amelioration of oxygen support in severe COVID-19 pneumonia.

  • 2022-12
  • RCT · n = 74
  • Clinical nutrition ESPEN 52
  • • Jananee Muralidharan
    • Sindhu Kashyap
    • Poorvikha S
    • Mathew Jacob
    • Anjali Ollapally
    • Jyothi Idiculla
    • John Michael Raj
    • Tinku Thomas
    • Anura V Kurpad

  • PubMed: 36513483
  • DOI: 10.1016/j.clnesp.2022.09.024

  3 Insights on

  • Reduced Time to Cessation of Oxygen Support

  • High evidence
  • Clinical

  The median number of days to the cessation of O2 support estimated using Kaplan Meir survival analysis, was 3 days in the l-Arg group (95% confidence interval [CI]: 1.2, 4.7) and 5 days in the placebo group (95% CI, 4.1,5.8); P = 0.27.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  3 g daily