L-Arginine and Reduced Vaso-occlusive Crisis

• The effects of nutritional supplementation for children and adolescents with sickle cell disease: A systematic review and meta-analyses.

  • 2025-04
  • Systematic Review · n = 2,058
  • Clinical nutrition (Edinburgh, Scotland) 47
  • • Bruna C Orsi
    • Daniela Gorski
    • Naila E Krul
    • Astrid Wiens
    • Miguel Brito
    • Fernanda S Tonin
    • Roberto Pontarolo

  • PubMed: 40022955
  • DOI: 10.1016/j.clnu.2025.02.016

  5 Insights on

  • Reduced Vaso-occlusive Crisis

  • High evidence
  • Clinical

  significantly improving pain intensity, vaso-occlusive crises (VOC) and inflammation when compared to usual care/placebo (p < 0.05).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes