L-Carnitine and Improved Maximal Walking Performance

• Propionyl-L-carnitine for intermittent claudication.

  • 2021-12-26
  • Meta-Analysis · n = 1,395
  • The Cochrane database of systematic reviews 2021(12)
  • • Victor Kamoen
    • Robert Vander Stichele
    • Laurence Campens
    • Dirk De Bacquer
    • Luc Van Bortel
    • Tine Lm de Backer

  • PubMed: 34954832
  • DOI: 10.1002/14651858.cd010117.pub2

  2 Insights on

  • Improved Maximal Walking Performance

  • High evidence
  • Clinical

  Mean improvement in ACD was slightly greater for PLC compared to L-carnitine, with a mean difference in absolute improvement of 20.00 meters (95% CI 0.47 to 39.53; 1 study, 14 participants) or a 16% relative improvement (95% CI 0.4% to 31.6%).

  Effect

  Neutral

  Effect size

  Small

  Significant

  Yes

  Dose

  not stated (comparator in single cross-over study)