L-Carnitine and Improved Pain-Free Walking Distance

• Propionyl-L-carnitine for intermittent claudication.

  • 2021-12-26
  • Meta-Analysis · n = 1,395
  • The Cochrane database of systematic reviews 2021(12)
  • • Victor Kamoen
    • Robert Vander Stichele
    • Laurence Campens
    • Dirk De Bacquer
    • Luc Van Bortel
    • Tine Lm de Backer

  • PubMed: 34954832
  • DOI: 10.1002/14651858.cd010117.pub2

  2 Insights on

  • Improved Pain-Free Walking Distance

  • High evidence
  • Clinical

  We found no evidence of a clear difference in the ICD (absolute improvement 4.00 meters, 95% CI -9.86 to 17.86; 1 study, 14 participants); or a 3% relative improvement (95% CI -7.4% to 13.4%).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  not stated (comparator in single cross-over study)