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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Carnitine and Improved Progressive Sperm Motility

Doses used in studies

g/day: 15 (median 15, IQR 15–15) — 1 study

Time to effect

Median: 3 months · IQR 3 months–3 months · Range 3 months–3 months — Reported in 1 of 2 studies

2 of 2 papers

Comparison of L-Carnitine vs. Coq10 and Vitamin E for idiopathic male infertility: a randomized controlled trial.
- 2022-07-01
- RCT · n = 143
- European review for medical and pharmacological sciences 26(13)
- - L Ma
  - Y Sun
- PubMed: 35856361
- DOI: 10.26355/eurrev_202207_29194
5 Insights on
- Improved Progressive Sperm Motility
- High evidence
- Large Human Trial
- Clinical
only progressive sperm motility and morphology improved in the control group
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
100 mg tablet orally, thrice daily
Effects of Carnitine and Coenzyme Q10 on Sperm Quality and Pregnancy Rates in Men with Unexplained Infertility: A Systematic Review and Network Meta-Analysis.
- 2025-08-14
- Systematic Review
- Reproductive sciences (Thousand Oaks, Calif.) 32(9)
- - Changmin Niu
  - Xueyu Lu
  - Yue Xie
  - Yawen Yu
  - Yuxin Gao
  - Nuo Shen
  - Ying Zheng
- PubMed: 40813743
- DOI: 10.1007/s43032-025-01958-9
2 Insights on
- Improved Progressive Sperm Motility
- High evidence
- Clinical
L-Carnitine has the greatest improvement effect on progressive sperm motility (SMD 4.19 [95% CI: 1.60 to 10.95]).
Effect
Beneficial
Effect size
Large
Significant
Yes