L-Carnitine and Improved Sperm Quality

• Effects of Carnitine and Coenzyme Q10 on Sperm Quality and Pregnancy Rates in Men with Unexplained Infertility: A Systematic Review and Network Meta-Analysis.

  • 2025-08-14
  • Systematic Review
  • Reproductive sciences (Thousand Oaks, Calif.) 32(9)
  • • Changmin Niu
    • Xueyu Lu
    • Yue Xie
    • Yawen Yu
    • Yuxin Gao
    • Nuo Shen
    • Ying Zheng

  • PubMed: 40813743
  • DOI: 10.1007/s43032-025-01958-9

  2 Insights on

  • Improved Sperm Quality

  • High evidence
  • Clinical

  L-carnitine, coenzyme Q10 and L-carnitine + acetyl-L-carnitine significantly improved sperm quality parameters compared with placebo.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• L-Carnitine and Male Fertility: Is Supplementation Beneficial?

  • 2023-09-06
  • Review
  • Journal of clinical medicine 12(18)
  • • Filipa G Mateus
    • Silvia Moreira
    • Ana D Martins
    • Pedro F Oliveira
    • Marco G Alves
    • Maria de Lourdes Pereira

  • PubMed: 37762736
  • DOI: 10.3390/jcm12185796

  4 Insights on

  • Improved Sperm Quality

  • Low evidence

  This supplementation enhances sperm parameters, regulates hormone levels, reduces ROS levels, and subsequently improves fertility rates.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  2 g/day