L-Carnitine and Increased Trimethylamine-N-Oxide Level

• The bright and the dark sides of L-carnitine supplementation: a systematic review.

  • 2020-01-03
  • Systematic Review · n = 11
  • Journal of the International Society of Sports Nutrition 17(1)
  • • Angelika K Sawicka
    • Gianluca Renzi
    • Robert A Olek

  • PubMed: 32958033
  • DOI: 10.1186/s12970-020-00377-2

  6 Insights on

  • Increased Trimethylamine-N-Oxide Level

  • High evidence
  • Adults

  LC supplementation was also noted to induce an increase of fasting plasma trimethylamine-N-oxide (TMAO) levels, which was not associated with modification of determined inflammatory nor oxidative stress markers.

  Effect

  Harmful

  Effect size

  Small

  Significant

  Yes

  Dose

  1 g to 4 g per day for either 12 or 24 weeks