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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Carnitine and Reduced Caspase-3 Level

Doses used in studies

mg/kg/day: 50 (median 50, IQR 50–50) — 1 study

Time to effect

Median: 6.6 months · IQR 3.8 months–9.4 months · Range 4.3 weeks–12.2 months — Reported in 2 of 2 studies

2 of 2 papers

L-carnitine decreases myocardial injury in children undergoing open-heart surgery: A randomized controlled trial.
- 2024-04-03
- RCT · n = 60
- European journal of pediatrics 183(6)
- - Wael El Feky
  - Dalia El-Afify
  - Dina Abdelhai
  - Mohamed Elkashlan
  - Ahmed Fakhreldin
  - Doaa El Amrousy
- PubMed: 38568244
- DOI: 10.1007/s00431-024-05534-2
8 Insights on
- Reduced Caspase-3 Level
- High evidence
- Clinical
L-carnitine group had significantly lower post-operative level of ... apoptosis markers (fas and caspase-3)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
50 mg/kg/day once daily for 1 month before cardiac surgery
Comparing the effectiveness of L-carnitine and paraffin oil in acute aluminum phosphide poisoning using predictive biomarkers and scores: A randomized controlled clinical trial.
- 2023-01-02
- RCT · n = 96
- Human & experimental toxicology 42
- - Walaa G Abdelhamid
  - Mahmoud L Sakr
  - Olfat E Mostafa
  - Dalia Zaafar
  - Hanan M Abdelwahab
- PubMed: 36592154
- DOI: 10.1177/09603271221149650
7 Insights on
- Reduced Caspase-3 Level
- High evidence
- Clinical
12 hours after admission, many clinical and biochemical data improved in both intervention groups including cytochrome c oxidase, caspase-3, caspase-9, catalase, and superoxide dismutase.
Effect
Beneficial
Effect size
Moderate
Significant
Yes