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Evidence-Based Supplement Research

Evidence-Based Supplement Research

L-Carnitine and Reduced Erythrocyte Sedimentation Rate

Doses used in studies

g/day: 3 (median 3, IQR 3–3) — 1 study
mg/day: 3,000 (median 3,000, IQR 3,000–3,000) — 1 study

Time to effect

Median: 6 days · IQR 6 days–7 days · Range 5 days–7 days — Reported in 2 of 2 studies

Safety in these studies

mortalityNo significant differencesix patients (14%) in the control group died due to the complications of COVID-19, while all patients in the intervention group survived
No significant differences were observed in terms of clinical symptoms; however, six patients (14%) in the control group died due to the complications of COVID-19, while all patients in the intervention group survived.
from: Effects of L-carnitine supplementation in patients with mild-to-moderate COVID-19 disease:
Overall tolerabilityReported
No significant differences were observed in terms of clinical symptoms
from: Effects of L-carnitine supplementation in patients with mild-to-moderate COVID-19 disease:

2 of 2 papers

The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial.
- 2024-03-06
- RCT · n = 60
- Nutrition journal 23(1)
- - Mahdi Keshani
  - Babak Alikiaii
  - Zahra Babaei
  - Gholamreza Askari
  - Zahra Heidari
  - Manoj Sharma
  - Mohammad Bagherniya
- PubMed: 38444016
- DOI: 10.1186/s12937-024-00934-4
9 Insights on
- Reduced Erythrocyte Sedimentation Rate
- High evidence
- Clinical
ESR (p: 0.004) significantly reduced in the LC group after 7 days.
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
3 g/day
Effects of L-carnitine supplementation in patients with mild-to-moderate COVID-19 disease: a pilot study.
- 2022-08-23
- RCT · n = 75
- Pharmacological reports : PR 74(6)
- - Seyed Saman Talebi
  - Mehran Ghasemi
  - Maryam Etminani-Esfahani
  - Younes Mohammadi
  - Rasool Haddadi
- PubMed: 35997951
- DOI: 10.1007/s43440-022-00402-y
9 Insights on
- Reduced Erythrocyte Sedimentation Rate
- High evidence
- Clinical
Mean erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were significantly lower in the intervention group.
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
3000 mg oral L-carnitine daily in three divided doses for five days